| 国产布洛芬缓释片的体内外相关性 |
| |
| 引用本文： | 李雪宁,陈伟力. 国产布洛芬缓释片的体内外相关性[J]. 中国医院药学杂志, 2001, 21(4): 199-201 |
| |
| 作者姓名： | 李雪宁 陈伟力 |
| |
| 作者单位： | 复旦大学医学院附属中山医院，上海 200032 |
| |
| 摘 要： | 目的对国产布洛芬缓释片的体内外相关性进行研究。方法体外释放度采用中国药典1995年版二部的转篮法，体内血药浓度用HPLC法和3P97程序计算药动学参数。结果在7h时平均累积释放77.44%；10名男性健康志愿者口服单剂量600mg布洛芬缓释片的体内过程符合开放一室模型，AUC,C
|
| 关 键 词： | 布洛芬 释放度 生物利用度 体内外相关性 缓释片 清炎药 |
| 文章编号： | 1001-5213(2001)04-0199-03 |
| 修稿时间： | 2000-04-29 |
In vivo and vitrocorrelation of domestic sustained release tablet of ibuprofen |
| |
| LI Xue Ning,CHEN Wei Li. In vivo and vitrocorrelation of domestic sustained release tablet of ibuprofen[J]. Chinese Journal of Hospital Pharmacy, 2001, 21(4): 199-201 |
| |
| Authors: | LI Xue Ning CHEN Wei Li |
| |
| Abstract: | OBJECTIVE To study in vivo and vitro correlation of domesticsustained release tablet of ibuprofen.METHODS The dissolution of ibuprofen was determined in vitro according to CP(1995,II) and the blood concentration in vivo by HPLC. The 3P97 program was used to calculate the pharmacokinetic parameters of ibuprofen. RESULTS The dissolution of ibuprofen was 77.44% within 7h, the AUC, Cmax, Tmax were (150.2±34.8) μg·h·ml-1,(22.7±5.3) μg·ml-1 and (3.5±0.7) h respectively. CONCLUSIONS There was significant correlation between in vitro dissolution and in vivo absorption of the tablet. |
| |
| Keywords: | ibuprofen dissolution bioavailability correlation in vivo and vitro |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
