抑制素B在正常子宫内膜及外周血中表达的相关性分析

目的研究正常子宫内膜组织INH亚单位的表达及分布情况以及外周血中INH—B水平以探讨INH在子宫内膜中的作用。方法选择2006年1月～12月就诊的输卵管因素不孕者的增殖期子宫内膜16例，宫颈癌患者之早分泌期（11例）和晚分泌期子宫内膜（17例）进行免疫组化检测。于月经第3～5天或经前第7天抽取外周血检测INH—B。所有病例术前半年未服任何激素类药物。结果INH三个亚单位在正常子宫内膜组织中表达，随月经周期的变化染色反应逐渐增强。在正常增殖期子宫内膜组织中BB亚单位的表达与血INH—B水平呈正相关（r=0．539，0．767，P〈0．05）。结论INH亚单位在正常子宫内膜组织中的表达及在外周血中表达的相关性说明了INH可能是自分泌和旁分泌信号的组成部分，在子宫内膜成熟过程中起重要作用。

The relationship of inhibin-B in serum and endometrium

Objective To detect the frequency and tissue distribution pattern of inhibin subunits in normal endometrium and periph-eral blood, and investigate the precise action in endometrium. Methods Normal cndometrial tissues were obtained from 16 women in the proliferative phase with salpingo-infertility, 11 women in the early secretory phase and 17 women in the late secretory phase with cervical cancer from Jan to Dee 2006. Expression of INH subunits were detected by immunohistochcmistry. INH-B in the blood samples were detec-ted. None of patients took any steroid drugs before 6 months of giving the samples. Results Immunohistochemistry showed that INH sub-units expressed in normal endometrial tissues. The expression intensity of INH subunits gradually increased in different menstrual phases. The level of inhibin-B in proliferative phase was higher than that in late secretory phase. Conclusions The relationship of inhibin-B level in serum and expression of inhibin subunits in endometrium showed that inhibin could be involved in autocrine/paracrine signaling and contrib-ute to several aspects of endometrial maturation.