Idiopathic Membranous Nephropathy with Solitary Immunoglobulin A Deposition: A Case Report and a Review of the Literature |
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| Authors: | Bin Li Hailiu Huang Shicong Yang Xin Wang Wei Chen Zhijian Li Xionghui Chen |
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| Affiliation: | 1.Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, China; 2.Key Laboratory of Nephrology, Ministry of Health, China; 3.Guangdong Provincial Key Laboratory of Nephrology, China; 4.Department of Nephrology, The Second People''s Hospital of Zhaoqing, China; 5.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, China |
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| Abstract: | A 63-year-old man with an 8-year history of proteinuria was diagnosed with nephrotic syndrome, and a renal biopsy was performed. Light and electron microscopic analyses showed classic features of idiopathic membranous nephropathy (IMN). However, immunofluorescence tests revealed solitary polyclonal granular IgA deposition along the glomerular capillary walls, rather than IgG, which is often dominant in IMN. The combined use of corticosteroids and calcineurin inhibitor was noticeably effective in reducing proteinuria and improving edema in the current case. Two additional rare cases of IMN with solitary IgA deposition were reviewed, and long-term surveillance is still warranted to characterize its clinicopathological features and outcome. |
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| Keywords: | membranous nephropathy solitary polyclonal IgA deposition rare disease case report |
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