Association between TGF-β gene polymorphism and myopia: A systematic review and meta-analysis |
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Authors: | Xiaoyu Zhu Bowei Xu Lingxue Dai Zuoyuan Wang Li Feng Jiangyue Zhao |
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Affiliation: | a Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University; Shenyang 110005, China;b Eye Hospital of China Medical University; Shenyang 110005, China;c Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, China;d Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, 200040, China. |
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Abstract: | Introduction:The present study was conducted to determine the association of transforming growth factor-beta (TGF-β) gene polymorphism and myopia.Method:Four hundred twelve articles were identified, of which 11 articles with 5213 participants in 4 countries were included in the final analysis. Review Manager software (RevMan, version 5.4) was used for data analysis.Result:Odds ratio (OR) value of TGF-β1 rs1800469 is 1.33 (95% confidence interval [CI] = 1.15–1.54) in the allelic model; in the dominant model is 1.76 (95% CI = 1.16–2.67); in homozygous model is 5.98 (95% CI = 4.31–8.06). OR value of TGF-β1 rs4803455 is 0.62 (95% CI = 0.43–0.88) in recessive model. TGF-β2 is not associated with myopia. Relevant study on TGF-β3 is scarce.Conclusion:Our systematic review and meta-analysis found that TGF-β1 rs4803455 and rs1800469 were correlated with myopia. |
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Keywords: | gene polymorphism, myopia, scleral remodeling, TGF-β |
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