Hematological alterations and thymic function in newborns of HIV-infected mothers receiving antiretroviral drugs |
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Authors: | Rotjanee Wongnoi Nawaporn Penvieng Panthong Singboottra Doungnapa Kingkeow Peninnah Oberdorfer Pannee Sirivatanapa Sakorn Pornprasert |
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Institution: | 1169. Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang-Mai University, Chiang-Mai, Thailand 2169. Research Institute for Health Sciences, Chiang-Mai University, Chiang-Mai, Thailand 3169. Department of Pediatrics, Chiang-Mai University, Chiang-Mai, Thailand 4169. Obstetrics and Gynecology; Faculty of Medicine, Chiang-Mai University, Chiang-Mai, Thailand 5169. Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang-Mai University, 110 Intawaroros Road, Chiang-Mai, Thailand, 50200
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Abstract: | Objectives To investigate the effects of antiretroviral (ARV) drugs on hematological parameters and thymic function in HIVuninfected newborns of HIV-infected mothers. Study design Cross sectional study. Setting Chiang-Mai University Hospital, Chiang-Mai, Thailand. Participants/Patients 49 HIV-uninfected and 26 HIV-infected pregnancies. Methods Cord blood samples of newborns from HIV-uninfected and HIV-infected mothers were collected. Hematological parameters were measured using automatic blood cell count. T-cell receptor excision circles (TRECs) levels in cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells were quantified using real-time PCR. Main Outcome Measures Hemotological parameters and thymic function. Results Newborn of HIV-infected mother tended to have lower mean levels of hemoglobin than those of HIV-uninfected mother (137 ± 22 vs 146 ± 17 g/L, P = 0.05). Furthermore, mean of red blood cell (RBC) counts and hematocrit and median of TRECs in CD4+ T-cells in the newborns of the former were significantly lower than those of the latter 3.6 ± 0.7 vs 4.8 ± 0.6 × 1012 cells/L, P <0.001; 0.40 ± 0.07 vs 0.46 ± 0.05 L/L, P <0.001 and 0.53 (IQR: 0.03–5.76) vs 13.20 (IQR: 2.77–27.51) × 10?3 pg/μL, P = 0.02, respectively]. Conclusion ARV drugs altered hematological parameters and thymic function (TRECs CD4+ T-cells) in HIV-uninfected newborns of HIV-infected mothers. |
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