A Territory-wide,Multicenter, Age- and Prostate-specific Antigen-matched Study Comparing Chemohormonal Therapy and Hormonal Therapy Alone in Chinese Men With Metastatic Hormone-sensitive Prostate Cancer |
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Authors: | Jeremy YC Teoh Darren MC Poon Daisy Lam Tim Chan Michelle FT Chan Eric KC Lee Snow Law Kuen Chan Nicole M Cheng Kai-Man Lai Chi-Ho Leung Chi-Fai Ng |
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Institution: | 1. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China;2. Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China;3. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China;4. Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China;5. Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, China;6. Department of Oncology, Princess Margaret Hospital, Hong Kong, China;7. Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China |
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Abstract: | BackgroundThere is a lack of real-world data regarding the treatment outcomes of chemohormonal therapy versus hormonal therapy alone in Chinese men with metastatic hormone-sensitive prostate cancer.Patients and MethodsWe conducted a territory-wide, multicenter, age- and prostate-specific antigen (PSA)-matched cohort study comparing chemohormonal therapy and hormonal therapy alone in Chinese men with metastatic hormone-sensitive prostate cancer. Patient and disease characteristics were reviewed. The primary outcome was PSA progression-free survival. Secondary outcomes included clinical progression-free survival and castration resistance-free survival. Kaplan-Meier and multivariate Cox regression analyses were performed.ResultsFrom January 2015 to July 2016, 32 Chinese men with metastatic hormone-sensitive prostate cancer were treated with chemohormonal therapy, and they were matched to 32 Chinese men who were treated with hormonal therapy alone. Patient and disease characteristics were similar between the 2 groups. The chemohormonal therapy group had a significantly better PSA progression-free survival (P = .001) and castration resistance-free survival (P = .002) than the hormonal therapy group. There was no significant difference in the clinical progression-free survival between the 2 groups. Upon multivariate Cox regression analyses, the use of chemohormonal therapy was significantly associated with a longer time to PSA progression (hazard ratio, 0.31; 95% confidence interval, 0.31-0.73; P = .008) and a longer time to castration resistance (hazard ratio, 0.38; 95% confidence interval, 0.17-0.83; P = .015), but was not associated with clinical progression.ConclusionsThe use of chemohormonal therapy could prevent PSA progression and the development of castration resistance when compared with hormonal therapy alone in Chinese men with metastatic hormone-sensitive prostatic cancer. |
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Keywords: | Chemotherapy Hormonal therapy Metastatic prostate cancer |
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