金属硫因蛋白、增殖细胞核抗原和肿瘤抑制基因p53在涎腺腺样囊性癌表达的研究

本研究对金属硫因蛋白(metallothionein,MT)、增殖细胞核 抗原(proliferating cell nuclearantigen,PCNA)和肿瘤抑制基因p53与涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)患者预后之间的关系进行了研究。通过对50例SACC的MT、PCNA与p53免疫组织化学反应及临床资料分析,结果表明:MT的表达与SACC患者生存率明显相关(P<0.05),它能在一定程度上判断SACC患者的预后情况;PCNA是评价细胞增殖状态的指标,PCNA的表达与SACC远处转移存在明显相关(P<0.05),肿瘤细胞增殖能促进SACC的远处转移;p53基因在SACC的发生发展过程中的作用不明显,可能存在其它某种或多种基因发挥更重要的作用。

The expression of metallothionein, proliferating cell nuclear antigen and p53 in salivary adenoid cystic carcinoma

In this study , the relationship between metallothionein (MT) proliferating cell nuclear anti-gen(PCNA) ,p53 and prognosis of the patients with salivary adenoid cystic carcinoma (SACC) were investigated,and the immunoactivity of MT,PCNA,p53 and clinical data of 50 cases were analysed. The results showed: the expression levels of MT significantly relate to the survival rate of the patients with SACC (P<0.05) ,and can predict the prognosis of the patients with SACC to some extent;PCNA is the marker for cell proliferation. The expression levels of PCNA have significant relation with distant metastasis of SACC (P<0.05) .which indicates that the proliferation of tumor cells can promote' distant metastasis of SACC; The mutational change in p53 is not important in the development of SACC, there mighe be one or some other genes playing more important roles in the development of this tumor.