肺硬化性血管瘤临床病理分析

 目的 探讨肺硬化性血管瘤（SHL）的临床病理特点。方法 对11例肺硬化性血管瘤进行光镜和免疫组化观察并结合文献进行分析。结果 SHL主要由圆形细胞和表面立方细胞二种细胞类型组成。组织结构多样，主要表现为实性区、乳头区、血管瘤样区和硬化区等四种结构。免疫组化标记二种细胞共同表达TTF-1和EMA。 结论 SHL为起源于原始的呼吸道上皮细胞的肿瘤，实性的圆形细胞和表面的立方细胞均为肿瘤细胞。形态应与炎性假瘤、肺Ⅱ型细胞乳头状瘤、肺泡腺瘤、典型类癌鉴别。部分SHL有侵袭性生长的倾向，外科手术治疗宜行肺叶切除术而非肿块剥离术。

Sclerosing hemangioma: a clinicopathological study of lung

Objective To study the clinicopathologic characteristics of pulmonary sclerosing hemangioma (SH) . Method Eleven cases of SH were studied by the clinical data and immunohistochemistry and review of the literature. Results SH has a characteristic architecture composed of round cell and surface cubic cell. It has a variety of tissular structure,mainly expression with four regions that contain solid regions, papillary regions, an-giomatoid regions and sclerosing regions. Immunohistochemically, these two kinds of cells were both positive for TTF-1 and EMA. Conclusions SH is a tumor that originates from the epithelial cell of primary respiratory tract. Both the solid round cells and surface cubic cells are neoplastic. SH should differential with inflammatory, typeⅡpneumocyte papillary tumor, alveolus adenoma and typical carcinoid tumors. The parts of SH have invade grow tendency. Surgical cure of SH is suited for operating a lobe of the lung but not just peel of the tumor.