| 肺炎衣原体感染与冠心病关系的初步探讨 |
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| 引用本文： | 吴晓燕,魏兵,冯永堂,苗乃法,徐志伟.肺炎衣原体感染与冠心病关系的初步探讨[J].潍坊医学院学报,2002,24(2):101-103. |
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| 作者姓名： | 吴晓燕 魏兵 冯永堂 苗乃法 徐志伟 |
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| 作者单位： | 潍坊医学院免疫学教研室,山东,潍坊,261042 |
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| 基金项目： | 山东省教育厅资助课题 (课题号 :1 998 0 2 1 1 35) |
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| 摘 要： | 目的 探讨肺炎衣原体感染与冠心病发病关系及发病机制。方法 用ELISA法检测冠心病患者血清中肺炎衣原体IgA ,IgG抗体阳性率 ,并与健康对照组进行比较。结果 经检测发现 ,冠心病患者中肺炎衣原体抗体IgA阳性率 4 7.4 % ,明显高于健康人 (P <0 .0 1) ,但是冠心病患者IgG阳性率与健康人无明显差别。结论 肺炎衣原体感染与冠心病有相关性 ,可能是诱发或加重冠心病病情的原因之一。
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| 关 键 词： | 肺炎衣原体 抗体 冠心病 |
| 文章编号： | 1004-3101(2002)02-0101-03 |
| 修稿时间： | 2001年8月20日 |
Chronic Chlamydia Pneumoniae Infection as a Risk Factor for Coronary Heart Disease |
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| WU Xiao-yan,WEI Bing,FENG Yong-tang,MIAO Nai-fa,XU Zhi-wei.Chronic Chlamydia Pneumoniae Infection as a Risk Factor for Coronary Heart Disease[J].Journal of Weifang Medical College,2002,24(2):101-103. |
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| Authors: | WU Xiao-yan WEI Bing FENG Yong-tang MIAO Nai-fa XU Zhi-wei |
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| Abstract: | Objective To investigate the association and pathogenesis between chronic chlamydia pneumoniae infection and chronic coronary heart disease(CCHD).Method Immunoglobulin A (IgA) and G (IgG) antibodies to chlamydia pneumoniae were measured using the ELISA in 54 sera samples from patient and 30 samples from healthy controls.Result Among CCHD cases,47% IgA antibody was positives,compared with 11% controls (P<0.01).But there were no significant differences between the two groups while detecting positive rate of IgG.Conclusion Chronic chlamydia infection shows a significant association with the development of CCHD.It is a risk factor for CCHD,IgA and its immune complexes is the pathologic events leading to atherosclerosis. |
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| Keywords: | Chlamydia pneumoniae Antibody Coronary heart disease |
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