益气活血通脉颗粒对动脉粥样硬化模型家兔NO、ET、bFGF的影响

为探讨益气活血通脉颗粒（主药：生黄芪、桃仁、地龙、桂枝）治疗动脉粥样硬化（AS）的机理。26只家兔分为正常对照组（A）、模型组（B）、百路达组（C）、卡托普利组（D）、益气活血通脉颗粒组（E）5组,除A组外,其余各组采用喂饲高胆固醇饲料加注射牛血清白蛋白的方法,建立AS模型,并给予不同的治疗：C、D、E组分别在高胆固醇饲料中加入相应药物。12周后,测定各组动物的外周血TC、TG、NO、ET,及主动脉bFGF含量与形态并评定病变程度。结果：各种药物均能升高AS兔NO、降低ET和动脉硬化程度,其中益气活血通脉颗粒的作用最佳,并能降低TC、TG。提示该药治疗AS的机理可能与其降低血脂、保护血管内皮细胞、调控bFGF的基因表达有关。

Influence of "Qi-Benefiting, Blood-Activating and Meridian-Dredging Granules" on NO. ET and bFGF in Arteriosclerosis Rabbits

In order to explore the mechanism of "Qi Benefiting, Blood Activating and Meridian Dredging Granules" (main ingredients: Radix Astragali, Semen Persicae, Lumbricus, Ramulus Cinnamomi) in the treatment of arteriosclerosis, 26 rabbits were divided into the normal control group (A), model group (B), Ginkgo Extract Capsules group (C), Captopril group (D) and "Qi Benefiting, Blood Activating and Meridian Dredging Granules" group (E). Except Group A, the rest groups were fed with high cholesterol forage plus injection of bovine serum albumin to create AS models and treated with different therapies. Group C, D and E were respectively added with corresponding drugs in forage. 12 weeks later, TC, TG, NO, ET of peripheral blood and aortic bFGF content and morphology were determined in the animals of various groups. The results showed that various drugs could elevate NO and decrease ET and arteriosclerosis degree in AS rabbits, and "Qi Benefiting, Blood Activating and Meridian Dredging Granules" was best and could decrease TC and TG. The findings indicate that the mechanism of this preparation in treating AS might be related to its functions to decrease blood fat, protect vascular endotheliocyte and regulate bFGF genetic expression.