Intensity-dependent effects of 1 Hz rTMS on human corticospinal excitability. |
| |
| Authors: | Paul B Fitzgerald Timothy L Brown Z Jeff Daskalakis Robert Chen J Kulkarni |
| |
| Institution: | Department of Psychological Medicine, Dandenong Psychiatry Research Centre, Monash University, P.O. Box 956, Victoria 3175, Australia. paul.fitzgerald@med.monash.edu.au |
| |
| Abstract: | OBJECTIVES: This study explored whether the effects of repetitive transcranial magnetic stimulation (rTMS) on corticospinal excitability are dependent on the stimulation intensity and examined the effect of rTMS on inhibitory function.METHODS: Nine normal volunteers received 15min of 1Hz rTMS at 85 and 115% of the resting motor threshold (RMT). Cortical excitability was measured before and after rTMS.RESULTS: rTMS at both intensities produced an increase in the RMT but only 115% stimulation reduced the size of motor evoked potentials (MEPs). rTMS had no effects on the cortical silent period or cortical inhibition measured with paired pulse TMS.CONCLUSIONS: The effects of 1Hz rTMS on motor cortex excitability are partially dependent on stimulus intensity and the effects of rTMS on motor thresholds and MEP size may differ. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
