女性生殖道病原体感染与晚期先兆流产的关系研究

目的：探讨女性生殖道白色念珠菌（CA）、解脲脲原体（UU）和沙眼衣原体（CT）感染与晚期先兆流产发生的关系。方法：选取2012年1月-2014年1月本院收治的66例晚期先兆流产患者作为观察组,同时随机选取同期80例正常中孕孕妇作为对照组,80例健康非孕已婚女性作为正常组。取白带做常规检查,其中CA用直接镜检,用培养法检测UU,取宫颈分泌物,用实时荧光定量PCR方法检测CT的DNA。结果：观察组白带常规白细胞、清洁度及乳酸杆菌异常率均明显高于对照组和正常组（P〈0.01）,而正常组和对照组间的乳酸杆菌异常率无明显差异（P〉0.05）;观察组与对照组的CA异常率均明显高于正常组（P〈0.01）,但观察组与对照组间无明显差异（P〉0.05）;观察组宫颈分泌中UU、CT、CT＋UU的检出率均明显高于对照组与正常组（P〈0.01）,而对照组与正常组间无明显差异（P〉0.05）。结论：生殖道UU和/或CT感染与晚期先兆流产发生密切相关,可能是其发生的重要原因之一。

The Study on Relationship between Female Genital Tract Infection with Pathogenic Organisms and Late Threatened Abortion

Objective：To investigate the relationship between female genital tract infection with Candida albicans（CA）,Ureaplasma urealyticum（UU） and Chlamydia trachomatis（CT） and late threatened abortion.Method：66 cervical secretion samples from patients with late threatened abortion（observation group）,80 samples from normal middle-stage pregnant women（control group） and 80 samples from healthy non-pregnant married women were selected in our hospital from January 2012 to January 2014.CA was detected by direct microscope examination,UU was detected by the culture method and CT DNA was detected by FQ-PCR.Result：The abnormal rate of WBC,cleanliness and lactic acid bacteria in observation group were significantly higher than those in control and normal group（P〈0.01）,but there was no significant difference in abnormal rate of lactic acid bacteria between normal group and control group（P〉0.05）.The abnormal rate of CA in observation group and control group were significantly higher than those in normal group（P〈0.01）,but there were no significant differences between observation group and control group（P〉0.05）.The detection rate of UU,CT,CT and UU in observation group were significantly higher than those in control group and normal group（P〈0.01）,but there were no significant differences between control group and normal group（P〉0.05）.Conclusion：As an important potential cause,the genital tract infection with UU and（or） CT may be closely related to the occurrence of late threatened abortion.