术前血小板与淋巴细胞比值对结直肠癌预后的影响

目的：讨论术前血小板/淋巴细胞比值（PLR）对结直肠癌患者预后的影响。方法：选取2007年6月-2012年6月本院收治的150例结直肠癌患者作为研究对象,根据手术前、后常规血液检查结果,计算PLR。按照PLR是否〈250,将患者分为高值组（PLR≥250）28例和低值组（PLR〈250）122例。观察比较两组患者的一般资料、不同TNM分期和不同分化程度的5年存活率,以探讨PLR对结直肠癌患者预后的影响。结果：高值组结肠癌患者比例67.86%（19/28）明显高于低值组的45.90%（56/122）,接受腹腔镜手术比例14.29%（4/28）明显低于低值组的40.16%（49/122）,低值组的5年生存率77.05%（94/122）明显高于高值组的50.00%（14/28）,且高值组晚期患者（Ⅲ、Ⅳ期）和分化差患者（差及黏液性患者）的5年生存率分别为28.57%（4/14）和40.00%（4/10）,均明显低于低值组的62.90%（39/62）和75.00%（27/36）,差异均有统计学意义（P〈0.05）。结论：高PLR值结直肠癌患者的5年存活率显著低于低PLR值患者。PLR是判断结直肠癌患者预后情况的重要指标,值得在临床中运用。

The Effect of Platelet and Lymphocyte Ratio on the Prognosis of Colorectal Cancer

Objective：To discuss the preoperative platelet/lymphocyte ratio（PLR） impact on the prognosis of patients with colorectal cancer.Method：150 patients with colorectal cancer from June 2007 to June 2012 in our hospital were selected as research objects.According to the results of routine blood tests before surgery, calculating PLR.According to whether PLR250,patients were divided into high-value group（PLR≥250） for 22 cases and low-value group（PLR250） for 122 cases.The clinical general information,five-year survival rate in different TNM stages and different degrees of differentiation of two groups were observed and compared.The effect of PLR on the prognosis of patients with colorectal cancer were investigated.Result：The proportion of colon cancer in high-value group was 67.86%（19/28）,it was significantly higher than 45.90%（56/122） in low-value group,the proportion of undergoing laparoscopic surgery in high-value group was 14.29%（4/28）,it was significantly lower than 40.16%（49/122） in low-value group,five-year survival rate of low-value group was 77.05%（94/122）,it was significantly than 50.00%（14/28） of high-value group,The five-year survival rate of advanced cancer（Ⅲ,Ⅳ stage） and differentiation of patients（patients with poor and mucinous） in high-value group were 28.57%（4/14）and 40.00%（4/10）,they were significantly lower than 62.90%（39/62）and 75.00%（27/36） in low-value group,the differences were statistically significant（P〈0.05）.Conclusion：Fiveyear survival rate of high PLR value colorectal cancer patients is significantly lower than low PLR value patients.PLR is an important index to judge the prognosis of colorectal cancer patients,it is worth in clinical application..