| 复方盐酸曲马多分散片处方及制剂工艺 |
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| 引用本文： | 魏纪鲁,胡冠时.复方盐酸曲马多分散片处方及制剂工艺[J].中国医院药学杂志,2004,24(10):627-629. |
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| 作者姓名： | 魏纪鲁 胡冠时 |
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| 作者单位： | 济南军区总医院,山东,济南,250031 |
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| 摘 要： | 目的:制备以盐酸曲马多和对乙酰氨基酚为主药的分散片.方法:选用直接粉末压片技术,建立反相高效液相色谱法测定该制剂中盐酸曲马多和紫外分光光度法测定对乙酰氨基酚.结果:工艺简便,分散快,5min累积释放度达到80%,质量稳定.结论:该处方工艺制成的分散片符合中国药典的要求.
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| 关 键 词： | 盐酸曲马多 对乙酰氨基酚 分散片 粉末压片 |
| 文章编号： | 1001-5213(2004)10-0627-03 |
| 修稿时间： | 2003年11月29 |
Preparation and formula of compound tromadol hydrochloride dispersible tablets |
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| Wei Ji-lu,Hu Guan-shi.Preparation and formula of compound tromadol hydrochloride dispersible tablets[J].Chinese Journal of Hospital Pharmacy,2004,24(10):627-629. |
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| Authors: | Wei Ji-lu Hu Guan-shi |
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| Abstract: | OBJECTIVE To prepare a dispersant tablet of Tramadol Hydrochloride and Acetaminophen.METHODS Preparing the tablet by a process-powder direct-pressed process. The tablet was measured by HPLC and by UV spectra.RESULTS The process is simple with a high dispersity. The accumulating dissolution of 5 minute can be as high as 80%. The stability of the tablet was detected by 6-month accelerate test.CONCLUSION The dispersant tablet made by the present process and formula is met the standard of Chinese Pharmacopoeia. |
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