血管内光声成像的研究进展

血管内光声（IVPA）成像是近年来发展起来的一种微创血管内成像技术，结合了光声信号激发阶段光吸收较高的对比度和光声信号发射阶段超声检测较高的分辨率，根据斑块成分对光的吸收差异检测和区分动脉粥样硬化斑块，可对斑块的形态和成分做更为全面的了解。介绍IVPA成像系统的研究现状、血管内超声(IVUS)/IVPA组合成像导管的设计与改进，以及在光谱成像、热成像、分子成像和对冠状动脉支架成像方面的应用现状，指出目前存在的问题，并对未来的研究进行展望。

Progress of Intravascular Photoacoustic Imaging

Intravascular photoacoustic (IVPA) imaging is a newly developed interventional imaging modality to detect and distinguish atherosclerotic plaques based on the differences between the optical absorption characteristics of different plaque tissues. It combines the contrast of optical absorption with the spatial resolution of ultrasound for deep imaging to obtain comprehensive information of morphology and component of atherosclerotic plaques. In this paper, the progress of IVPA imaging system as well as its applications in spectroscopy imaging, thermal imaging, molecular imaging and coronary stent imaging was reviewed. The current development of integrated IVPA/IVUS imaging catheter is then summarized. The existing problems and future directions in the design and implement IVPA system were also discussed.