| Visfatin及其基因多态性与糖脂代谢的关系 |
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| 引用本文： | 张文博,田林红,罗晖,陈慧. Visfatin及其基因多态性与糖脂代谢的关系[J]. 国际内分泌代谢杂志, 2007, 29(1): 19-22. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.007 |
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| 作者姓名： | 张文博 田林红 罗晖 陈慧 |
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| 作者单位： | 730030兰州大学第二医院内分泌科; |
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| 基金项目： | 甘肃省技术研究与开发专项计划 |
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| 摘 要： | Visfatin是新近发现的一种脂肪细胞因子,主要由内脏脂肪组织分泌产生.目前许多研究表明,visfatin与胰岛素抵抗、脂代谢、2型糖尿病及其并发症密切相关,具有降血糖和类胰岛素作用,在2型糖尿病伴动脉粥样硬化、冠心病及糖尿病肾病患者中血浆水平明显升高.因此,visfatin可能与上述疾病的发生有一定关系.此外,visfatin基因多态性与糖脂代谢相关,而且受遗传背景和环境凶素的影响.本文就visfatin及其基因多态性与糖脂代谢关系的研究进展作一综述.
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| 关 键 词： | 单核苷酸基因多态性 胰岛素抵抗 糖脂代谢 |
Relationship between visfatin,its gene polymorphisms and glucose,lipid metabolism |
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| ZHANG Wen-bo,TIAN Lin-hong,LUO Hui,CHEN Hui. Relationship between visfatin,its gene polymorphisms and glucose,lipid metabolism[J]. International JOurnal of Endocrinology and Metabolism, 2007, 29(1): 19-22. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.007 |
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| Authors: | ZHANG Wen-bo TIAN Lin-hong LUO Hui CHEN Hui |
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| Abstract: | Visfatin is a novel adipocytokine synthesized mainly by visceral fat. Many studies have ex-plored the association of visfatin with insulin resistance, lipid metabolism, type 2 diabetes mellitus and its complications. It reduces plasma glucose by insulin-mimetic effects. The serum visfatin levels in patients with type 2 diabetes mellitus combined with atherosclerosis,coronary heart disease or diabetic nephropathy are sig-nificantly higher than those in controls. So it may be related to the pathogenesis of these diseases. Further-more, the single nucleotide polymorphisms of visfatin is related to glucose and lipid metabolism. It is also in-fluenced by genetic background and environmental factors. This article reviews recent progress in the relation-ship between visfatin, its gene polymorphisms and glucose, lipid metabolism. |
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| Keywords: | VisfatinVisfatinSingle nucleotide polymorphismsInsulin resistanceGlucose and lipid metabo-lism |
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