音乐对大鼠学习和记忆及海马NMDA受体表达的作用

目的研究音乐对大鼠空间学习和记忆的影响及对大鼠海马内NMDA受体的表达的影响。方法用Morris水迷宫中，位置非匹配任务行为检测方法，检测音乐刺激后，大鼠学习和记忆行为能力的变化，并用免疫组织化学、PCR技术，检测大鼠海马NMDA受体及编码NMDA受体的mRNA表达的变化。结果音乐刺激后，大鼠空间记忆能力改善，信息游泳逃和选择游泳逃避潜伏期缩短，选择游泳选择正确率提高；海马神经元NMDA受体及其mRNA表达增加。这些变化以持续音乐刺激组变化最明显，生后音乐组次之，对照组变化最小。结论音乐刺激能提高大鼠空间记忆能力，能增强大鼠海马神经元NMDA受体表达，增强海马组织编码NMDA受体的mRNA表达。

Effect of music on learning and memory and expression of NMDA receptor on rat hippocampus

Objective:To study the effect of music on spatial learning and memory and the expression of the NMDA receptor in rat hippocampus.Methods:The no-matched position task in the Morris's water maze was used to examine the behavior changes on learning and memory,and immunohistochemistry and PCR technique were carried out to measure the expression of NMDA receptor and mRNA coding the receptor on hippocampus from Wistar rats after music stimulation.Results:After music exposure the spatial memory of rats improved;the avoiding latency of information swim and choice swim shortened,and choice accuration in choice swim increased;the expression of NMDA receptor and the mRNA coding the NMDA receptor on hippocampus was strengthened.All these effects were the strongest in the persistent music treated group,moderate in the postnatal music treated group,and least in the control groups.Conclusion:Music can improve the spatial memory of rats and increase the expression of the NMDA receptor and the mRNA coding the NMDA receptor in hippocampus.