| 苦瓜多糖降血糖活性成分的研究 |
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| 引用本文： | 董英,张慧慧.苦瓜多糖降血糖活性成分的研究[J].营养学报,2008,30(1):54-56. |
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| 作者姓名： | 董英 张慧慧 |
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| 作者单位： | 江苏大学食品生物工程学院,镇江,212013 |
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| 摘 要： | 目的研究苦瓜多糖最佳降糖活性成分的降血糖功能及其机制。方法比较苦瓜水提多糖和苦瓜碱提多糖对链脲霉素(STZ)诱导的糖尿病小鼠的降糖效果,初步分析其降糖机制。结果苦瓜碱提多糖200和400mg/kgbw都可显著降低STZ糖尿病小鼠的血糖葡萄糖耐量及肝糖原的含量,果糖胺的含量同样也有所降低。分子量最大的苦瓜碱提多糖降糖活性最好。结论大分子量苦瓜多糖的降糖效果较好,其机制可能是通过减弱STZ对胰岛β细胞的损伤或改善受损β细胞的功能,从而起到调节血糖的作用。
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| 关 键 词： | 苦瓜 碱提多糖 血糖 葡萄糖耐量 |
| 文章编号： | 0512-7955（2008）01-054-03 |
| 收稿时间： | 2007-08-22 |
| 修稿时间： | 2007年8月22日 |
STUDIES ON COMPONENTS WITH ANTIHYPERGLYCEMIC EFFECT OF MOMORDICA CHARANTIA L. POLYSACCHARIDES |
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| DONG Ying,ZHANG Hui-hui.STUDIES ON COMPONENTS WITH ANTIHYPERGLYCEMIC EFFECT OF MOMORDICA CHARANTIA L. POLYSACCHARIDES[J].Acta Nutrimenta Sinica,2008,30(1):54-56. |
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| Authors: | DONG Ying ZHANG Hui-hui |
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| Abstract: | Objective To investigate the antihyperglycemic effect and the most effective com-ponent of Momordica charantia L. and its mechanism. Method Water-extracted and alkali-extracted Momordica charantia L. polysaccharides with different molecular weight on streptozotocin induced diabetes mellitus mice were carried out. The antihyperglycemic mechanism was preliminarily analyzed. Results Alkali-extracted Momordica charantia L. polysaccharides could lower blood sugar,improve glucose tolerance and increase the content of hepatic glycogen significantly at the dose of both 200 and 400mg/kg bw. The content of fructosamine was also lowered. Conclusion The component of alkali extracted Momordica charantia L polysacchaides with maximal molecular weight possessed the best antihyperglycemic effect. |
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| Keywords: | Momordica charantia L alkali-extracted polysaccharides blood glucoses glucose tolerance |
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