非小细胞肺癌EGF及其受体的表达意义

目的:探讨配体EGF和受体EGFR与非小细胞肺癌(NSCLC)的临床生物学行为及预后的关系. 方法:采用免疫组化法观察NSCLC患者33例及非癌肺疾病患者7例组织标本中EGF和EGFR的表达. 结果:EGF和EGFR在NSCLC患者中过表达率分别为57.6%和63.6%,其中EGFR过表达与NSCLC患者的TNM分期呈显著正相关(P<0.05). EGF或/和EGFR过表达的NSCLC患者生存期短、预后差(P<0.01). 结论:EGF和EGFR在NSCLC的发展和转移方面起重要作用,可作为评估NSCLC进展及判断预后的指标.

Significance of epidermal growth factor expression and its receptor in non-small cell lung cancer

AIM: To investigate the relation between the expression of epidermal growth factor (EGF) as well as its receptor(EGFR)and clinical biological behavior and prognosis of non small cell lung cancer(NSCLC). METHODS: By immunohistochemical method, 33 specimens of non small cell lung cancer and 7 cases of adjacent nonneoplastic lung tissues were examined for the expressions of EGF and EGFR. RESULTS: Of the 33 NSCLC cases, the overexpression rates of EGF and EGFR were 57.6% and 63.6% respectively and the overexpression of EGFR was positively related with TNM stages ( P <0.05). The mean survival time was significantly shorter in patients with high EGF and/or EGFR level than that in the patients with low EGF and/or EGFR level ( P <0.01). CONCLUSION: EGF and EGFR may play an important role in tumor progression and malignant metastasis of non small cell lung cancer, and their expressions can be of prognostic significance.