多西他赛节拍化疗治疗老年晚期非小细胞肺癌疗效观察 |
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引用本文: | 杨静,;王翔,;王晓友.多西他赛节拍化疗治疗老年晚期非小细胞肺癌疗效观察[J].徐州医学院学报,2014(10):665-668. |
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作者姓名: | 杨静 ;王翔 ;王晓友 |
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作者单位: | [1]徐州市中医院肿瘤内科,江苏徐州221003; [2]徐州市中心医院肿瘤内科,江苏徐州221009; [3]徐州医学院附属医院立体定向科,江苏徐州221002 |
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基金项目: | 徐州市科技局立项课题(XZD1-2010) |
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摘 要: | 目的探讨多西他赛单药节拍化疗一线治疗老年晚期非小细胞肺癌(NSCLC)的疗效及安全性。方法将20例老年晚期NSCLC患者作为节拍组(多西它赛25mg/m^2静脉滴注1h,第1、8、15天给药,每28天为1个周期),另20例为对照组(多西他赛75mg/m^2静脉滴注1h,第1天给药,每3周重复)。比较2组化疗2周期后的近期疗效、生活质量及毒性反应。结果节拍组近期疗效的有效率、临床受益率虽高于对照组,但差异无统计学意义(P〉0.05);节拍组患者化疗后生活质量改善情况优于对照组(P〈0.01),药物毒性反应较对照组轻(P〈0.05或P〈0.01)。结论多西他赛单药节拍化疗治疗老年晚期NSCLC患者安全有效,优于传统治疗方法。
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关 键 词: | 节拍化疗 多西他赛 非小细胞肺癌 老年 |
Clinical observation of metronomic docetaxel chemotherapy to treat advanced non -small cell lung cancer in elderly patients |
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Institution: | YANG Jing , WANG Xiang , WANG Xiaoyou ( 1. Department of Oneology, Xuzhou City Hospital of TCM, Xuzhou, Jiangsu 221003, China; 2. Department of Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009 ; 3. Department of Stereotaxis, the Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002) |
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Abstract: | Objective To explore the efficacy and safety of metronomic docetaxel monotherapy to treat advanced non - small cell lung cancer (NSCLC) in elderly patients. Methods Twenty elderly patients with advanced NSCLC were included into a treatment group who received metronomic docetaeel chemotherapy (through one hour of intravenous infusion with 25 mg/m^2 docetacel on Days 1,8 and 15, with a cycle length of 28 days). Meanwhile, another twenty patients were enrolled into a control group and given traditional docetaxel chemotherapy ( through one hour of intravenous infusion with 75 mg/m: docetacel on Day 1, which was repeated every three weeks). After two cycles of treatment, the short - term efficacy, quality of life and toxic reactions were compared between both groups. Results The treatment group presented a higher effective rate and better clinical benefit response (CBR) than the control group, in spite of no statistical difference ( P 〉 0.05 ). After metronomic therapy, the patients reported better quality of life ( P 〈 0.01 ) and less toxic reactions (P 〈 0.05 or P 〈 0.01 ) than those in the control group. Conclusion Metronomic doeetaxel chemotherapy is superior to the traditional regime with respect to its effectiveness and safely when applied to elderly patients with NSCLC. |
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Keywords: | metronomic chemotherapy docetaxel non- small cell lung cancer elderly patients |
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