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EFFECT OF ACTH ADMINISTRATION ON THE HAEMODYNAMIC RESPONSE TO ARGININE-VASOPRESSIN IN SHEEP |
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| Authors: | John P Coghlan Derek A Denton William F Graham Timothy J Humphrey Rex T Mason Edward G Schnieder† Bruce A Scoggins Judith A Whitworth |
| Institution: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia |
| Abstract: | 1. Blood pressure, heart rate and cardiac output were studied in intact conscious sheep during AVP infusion at 0.1, 0.25, 0.5 and 10 μg/min for 30 minutes to determine whether pressor responsiveness to AVP was altered in ACTH-induced hypertension. 2. Prior to ACTH treatment, AVP produced rises in blood pressure associated with a fall in heart rate and cardiac output. 3. During ACTH treatment, pressor responsiveness to AVP and decrease in cardiac output were unchanged, but reflex bradycardia was reduced. 4. ACTH-induced hypertension in sheep is not associated with enhanced pressor responsiveness to AVP. |
| Keywords: | ACTH arginine-vasopressin blood pressure cardiac output cardiac rate haemodynamics hypertension sheep steroids |