急性酒精摄入对小鼠血糖的影响

目的观察急性酒精摄入对小鼠血糖的影响。方法将雄性小白鼠随机分成高剂量组、中剂量组、低剂量组和对照组。用浓度为52%、26%、13%的乙醇按0.15ml/10g的剂量分别给高、中、低剂量组小鼠灌胃,对照组用生理盐水灌胃。40min后眼球采血,离心取血浆测定血糖含量。另将剩余的雄性小鼠随机分为3组,均用52%的乙醇按0.15ml/10g的剂量灌胃,分别在3h、6h和12h后测定血糖含量。结果高、中、低剂量组小鼠血糖均高于对照组小鼠血糖,且呈剂量依赖关系,高剂量组血糖最高（P〈0.01）。在高剂量酒精组急性高剂量酒精灌胃后40min、3h、6h、12h,小鼠血糖随时间延长而逐渐降低,12h血糖降至正常（P〈0.01）,但未出现低血糖。结论在一定酒精浓度范围内,急性酒精摄入可导致小鼠血糖升高,且随着酒精浓度的升高而升高;在高浓度酒精急性摄入后12h内,小鼠血糖随时间延长而降低,但未出现低血糖。

Influence of acute alcohol intake on blood glucose in mice

Objective To observe the effect of acute alcohol intake on blood glucose of mice.Methods Male mice were randomly divided into four groups,low-,middle-,high-dose group and control group.Rats were feed with13%,26%,52%alcohol in 0.15ml/10g,respectively,and the same dose of normal saline for the control group.Take the mice blood after 40 minutes to detect the serum glucose levels.Besides,other male mice were feed with 52% alcohol by 0.15ml/10g,detect the glucose levels after 3 hour,6 hour and 12 hour,respectively.Results The glucose levels in each of the four groups was higher than that of control group（P0.01）,and elevated with the increased alco-hol concentration;the glucose levels decreased significantly with the time after alcohol intake for 40min,3h,6h and 12h（P0.01）,but no hypoglycemia appeared.Conclusion Within a certain range of alcohol concentration,acute alcohol intake can lead to elevating serum glucose levels in mice,which was elevated with the increasing alcohol concentration.