玻璃体腔注射曲安奈德治疗显著性黄斑水肿的疗效观察

目的观察玻璃体腔注射曲安奈德(triamcinolone acetonide,TA)对显著性黄斑水肿的疗效.方法选择来该院门诊就医的12例显著性黄斑水肿患者,予玻璃体腔注射4 mg曲安奈德,分别于术前、术后1 d、1、4及12周进行视力、眼压、FFA、HRT-II检查并加以比较,进行统计学分析.结果术后1、4及12周最佳矫正视力与术前比较,有明显提高,差异有显著性(P＜0.01);HRT-II与术前比较好转,差异有显著性(P＜0.01);术后4周、12周眼压较术前升高,比较有显著性差异(P＜005),术后7 d眼压较术前升高,差异无显著性(P＞0.05);FFA显示黄斑水肿程度较术前减轻,渗漏减少.结论玻璃体腔注射曲安奈德对显著性黄斑水肿有明确疗效.

Clinical observation on intravitreal triamcinolone acetonide for treating significant macular edema

Objective To check the influence of intravitreal triamcinolone acetonide on clinically significant macular edema.MethodThis prospective study involvd 12 cases. The main outcome measures included best- cor- rected visual acuity, intraocular pressure, fundus fluoresce in angiography (FFA) and macular oedema map values of Heidelberg Retinal Tomograph II (HRT II) before and after intravitreal triamcinolone injection.ResultThe com- plaints of the best- corrected visual acuity and HRT II turned better at 7, 30, 120 days after operation than preoper- ation, with significant difference (P<0.01); The intraocular pressure turned higher at 30, 120 days after operation than preoperation, with significant difference (P<0.05), and with no significant difference at 7 days (P>0.05); FFA displayed the degree of macular edema lessened and leakage reduced.ConclusionThe operation of intravitreal Triamcinolone Acetonide can induce macular edema.