| 添加低聚半乳糖肠内营养对重症急性胰腺炎大鼠炎性细胞因子的作用 |
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| 引用本文： | 钟燕,蔡东联,耿珊珊,韩婷,陈凌云.添加低聚半乳糖肠内营养对重症急性胰腺炎大鼠炎性细胞因子的作用[J].上海交通大学学报(医学版),2009,29(6). |
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| 作者姓名： | 钟燕 蔡东联 耿珊珊 韩婷 陈凌云 |
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| 作者单位： | [1]上海交通大学医学院新华医院临床营养中心,上海200092 [2]第二军医大学长海医院营养科,上海200433 |
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| 摘 要： | 目的研究给予添加低聚半乳糖（GOS）肠内营养对重症急性胰腺炎（SAP）大鼠血清炎性细胞因子的作用。方法将SAP造模成功的32只SD大鼠随机分为普通肠内营养（EN）组（n=16）和GOS—EN组（N=16），同时设立假手术对照组（n=16），然后按照动物处死时间每组又分为4d和7d两个时间点亚组，每个亚组各8只动物。采用胰被膜下均匀注射38g／L牛磺胆酸钠法建立SAP大鼠模型，检测各时间点血清淀粉酶、血清促炎细胞因子TNF—α和抗炎细胞因子IL-2、IL-10水平。结果各SAP组的血清淀粉酶水平显著高于假手术对照组（P〈0．01），GOS—EN组显著低于EN组（P〈0．01）；各SAP组的TNF-α和IL-10水平均显著高于假手术对照组（P〈0．01），而IL-2显著低于假手术对照组（P〈0．01）。GOS—EN组的TNF-α水平显著低于EN组（P〈0．05），而IL-2、IL-10水平以及IL-10／TNF—α比值显著高于EN组（P〈0．05）。结论早期给予GOS—EN能够调节SAP大鼠促、抗炎细胞因子平衡。
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| 关 键 词： | 重症急性胰腺炎 低聚半乳糖 细胞因子 |
Effects of enteral nutrition with galactooligosaccharides on inflammatory cytokines in rats with severe acute pancreatitis |
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| ZHONG Yan,CAI Dong-lian,GENG Shan-shan,HAN Ting,CHEN Ling-yun.Effects of enteral nutrition with galactooligosaccharides on inflammatory cytokines in rats with severe acute pancreatitis[J].Journal of Shanghai Jiaotong University:Medical Science,2009,29(6). |
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| Authors: | ZHONG Yan CAI Dong-lian GENG Shan-shan HAN Ting CHEN Ling-yun |
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| Institution: | 1.Department of Nutrition;Xinhua Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200092;China;2.Department of Nutrition;Changhai Hospital;Second Military Medical University;Shanghai 200433;China |
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| Abstract: | Objective To investigate the effects of enteral nutrition with galactooligosaccharides(GOS) on serum inflammatory cytokines in rats with severe acute pancreatitis(SAP).Methods SD rats were randomly divided into sham operation control group,SAP with enteral nutrition(EN) group and SAP with EN supplemented with GOS(GOS-EN) group,and each group was divided into 4 d and 7 d subgroups according to the time that animals were sacrificed(n=8 in each subgroup).Rat SAP models were established by injection of 38 g/L s... |
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| Keywords: | severe acute pancreatitis prebiotics inflammatory cytokine |
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