| 血管内皮生长因子及其受体在先兆子痫大鼠肾损伤中的作用 |
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| 引用本文： | 苏华,朱忠华,张春,汪洪波,邓安国. 血管内皮生长因子及其受体在先兆子痫大鼠肾损伤中的作用[J]. 华中科技大学学报(医学版), 2003, 32(1): 46-50 |
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| 作者姓名： | 苏华 朱忠华 张春 汪洪波 邓安国 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院肾内科,武汉,430022 |
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| 基金项目： | 湖北省自然科学基金资助项目 ( No.2 0 0 0 J0 5 5 ) |
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| 摘 要： | 目的 研究血管内皮生长因子 ( VEGF)及其受体 ( VEGFR)在先兆子痫大鼠肾损伤中的作用。方法 采用一氧化氮合酶抑制剂复制大鼠先兆子痫模型 ,应用原位杂交法测定肾小球 VEGF m RNA转录水平 ,利用免疫组化法检测肾小球 VEGF和 VEGFR蛋白表达情况。结果 在先兆子痫大鼠中 ,肾小球局部 VEGF m RNA和 VEGF、VEGFR-2蛋白表达均增强 ,且表达的强度与 2 4h尿蛋白排泄量呈正相关。结论 肾小球 VEGF- VEGFR系统可能参与了先兆子痫中大量蛋白尿的产生
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| 关 键 词： | 血管内皮生长因子 先兆子痫 蛋白尿 |
| 修稿时间： | 2002-04-03 |
The Effect of Vascular Endothelial Growth Factor and Its Receptor in Kidney Lesion of Rats with Preeclampsia |
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| Su Hua,Zhu Zhonghua,Zhang Chun et al. The Effect of Vascular Endothelial Growth Factor and Its Receptor in Kidney Lesion of Rats with Preeclampsia[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2003, 32(1): 46-50 |
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| Authors: | Su Hua Zhu Zhonghua Zhang Chun et al |
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| Affiliation: | Su Hua,Zhu Zhonghua,Zhang Chun et al Department of Nephrology,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022 |
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| Abstract: | Objective To investigate the effect of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in kidney lesion of rats with preeclampsia. Methods A rat model of preeclampsia was developed by inhibitor of nitric oxide synthase. The level of VEGF mRNA in glomeruli was measured by in situ hybridization. The expression of VEGF and VEGFR in glomeruli was detected by immunohistochemistry method. Results In rats with preeclampsia, the level of VEGF mRNA and the expression of VEGF and VEGFR were significantly higher than other groups. There was a positive correlation between the expression of VEGF-VEGFR system in glomeruli and 24 h urinary protein excretion. Conclusion VEGF-VEGFR system in glomeruli might be involved in the mechanism of proteinuria in preeclampsia. |
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| Keywords: | vascular endothelial growth factor preeclampsia proteinuria |
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