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| ATP酶变化在1,2二氯乙烷致脑水肿过程中的作用研究 | |
| 引用本文： | 杨利军,牛侨,杨涛,梁友信,李来玉.ATP酶变化在1,2二氯乙烷致脑水肿过程中的作用研究[J].卫生研究,2002,31(6):458-459. |
| 作者姓名： | 杨利军 牛侨 杨涛 梁友信 李来玉 |
| 作者单位： | 1. 山西医科大学,太原,030001 2. 上海医科大学 3. 广东省职业病防治院 |
| 基金项目： | 山西省自然科学基金 (No .医Z991 0 72 ) |
| 摘 要： | 为探索Na+ K+ATP酶、Ca2 +、Mg2 +ATP酶在 1,2 -二氯乙烷 (1,2 DCE)致脑水肿过程中所起的作用 ,在复制脑水肿模型的基础上 ,检测受试动物脑组织中Na+ K+ATP酶、Ca2 +、Mg2 +ATP酶活力的变化。结果显示 ,随着染毒剂量的增加 ,Na+ K+ATP酶活力逐渐降低 ,最高剂量组与各组相比 ,具有显著性差异 ;Ca2 +、Mg2 +ATP酶活力显著下降 ,与其余各组相比 ,P <0 0 5。结果提示 :1,2 DCE引起了ATP酶活力的下降导致脑组织能量代谢障碍 ,从而可能引起“Ca2 +超载” ,ATP酶活力下降和“Ca2 +超载”可能是引起脑水肿的主要原因 |
| 关 键 词： | ATP酶 1 2二氯乙烷 脑水肿 Ca2+超载 |
| 文章编号： | 1000-8020(2002)06-0458-02 |
| 修稿时间： | 2002年2月7日 |
Study on changes of activity of ATPase in brain edema caused by 1,2-dichloroethane |
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| Yang Lijun,Niu Qiao,Yang Tao,Liang Youxin,et al..Study on changes of activity of ATPase in brain edema caused by 1,2-dichloroethane[J].Journal of Hygiene Research,2002,31(6):458-459. | |
| Authors: | Yang Lijun Niu Qiao Yang Tao Liang Youxin |
| Institution: | Yang Lijun,Niu Qiao,Yang Tao,Liang Youxin,et al. Shanxi Medical University,Taiyuan 030001,China |
| Abstract: | The effect of ATPase and Ca\+\{2+\}\|Mg\+\{2+\}ATPase in brain edema caused by 1,2\|dichloroethane (1,2\|DCE) was studied. The activity changes of ATPase and Ca\+\{2+\}\|Mg\+\{2+\}ATPase were observed in the edematous brain tissue. The results showed that the activities of ATPase and Ca\+\{2+\}\|Mg\+\{2+\} ATPase were decreased with the inhalation dose increasing, the group of 10.0 g/m\+3 has significant difference compared with the control group. The study suggests that the Ca\+\{2+\}overload result in brain edema owing to the retard of energy metabolism which was caused by decreasing of ATPase activity. So the decreasing of ATPase activity and the Ca\+\{2+\}overload may play a great role in brain edema caused by 1,2\|DCE. |
| Keywords: | ATPase 1 2\|dichloroethane brain edema Ca\+\{2+\} overload |
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