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| 斑秃患者血浆内皮素及血清一氧化氮水平测定及其意义 | |
| 引用本文： | 冯进云,芦王英,吴志华.斑秃患者血浆内皮素及血清一氧化氮水平测定及其意义[J].岭南皮肤性病科杂志,2004,11(3):205-206,209. |
| 作者姓名： | 冯进云 芦王英 吴志华 |
| 作者单位： | 1. 广东省广州市第八人民医院皮肤科,广东,广州,510060 2. 广东医学院寄生虫学教研室,广东,湛江,524023 3. 广东医学院皮肤性病研究所,广东,湛江,524001 |
| 摘 要： | 目的 :探讨血浆内皮素 (ET)和血清一氧化氮 (NO)在斑秃发病中的作用。方法 :应用放射免疫法和Greiss法测定 2 3例斑秃活动期患者、1 1例斑秃稳定期患者以及 2 5例正常人血浆ET和血清NO值。结果 :斑秃活动期患者ET水平和ET/NO比值显著高于正常人 (P <0 0 5 ) ,但其NO水平与正常人无显著性差异 (P >0 0 5 ) ;斑秃稳定期ET和NO水平以及ET/NO比值与正常人无显著性差异(P >0 0 5 )。结论 :斑秃活动期患者ET水平和ET/NO比值可能与斑秃的活动性有关 |
| 关 键 词： | 斑秃 患者 正常人 血清一氧化氮 血浆内皮素 ET 活动期 测定 |
| 文章编号： | 1009-8968(2004)03-0205-03 |
| 修稿时间： | 2004年6月9日 |
Detection of Plasma Endothelin and Serum Nitric Oxide in Patients with Alopecia Areata and Its Clinical Significance |
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| FENG Jin-yun,LU Wang-ying,WU Zhi-hua.Detection of Plasma Endothelin and Serum Nitric Oxide in Patients with Alopecia Areata and Its Clinical Significance[J].Southern China Journal of Dermato-Venereology,2004,11(3):205-206,209. | |
| Authors: | FENG Jin-yun LU Wang-ying WU Zhi-hua |
| Abstract: | Objective:To investigate the correlation between expression of plasma endothelin (ET) and serum nitric oxide (NO) in patients with alopecia areata(AA) and clinical severity of the disease. Methods:The levels of plasma ET and serum NO were respectively detected by radio-immunoassay and Greiss reaction in 23 patients with active AA, 11 patients with stable AA and 25 normal controls. Results:Compared with those in normal controls, the levels of plasma ET and ET/NO in patients with active AA were statistics significant(P<0.05),but the serum NO was not significant; there was no statistics significance in the levels of plasma ET, serum NO and ET/NO between patients with stable AA and normal controls. Conclusion:ET and ET/NO may be involved in the pathogenesis of AA. |
| Keywords: | alopecia areata endothelin nitric oxide |
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