| 粉防己碱在急性缺血性肾损伤中的作用及与磷脂酶A_2的关系 |
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| 引用本文： | 钱玲梅,王笑云. 粉防己碱在急性缺血性肾损伤中的作用及与磷脂酶A_2的关系[J]. 南京医科大学学报(自然科学版), 1998, 0(1) |
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| 作者姓名： | 钱玲梅 王笑云 |
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| 作者单位： | 南京医科大学第一附属医院肾内科!南京210029 |
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| 摘 要： | 采用双肾完全缺血45分钟大鼠模型，观察粉防已碱在急性缺血性肾损伤中的保护性作用及其与磷脂酶A2的关系。结果表明：肾损伤治疗组血清磷脂酶A2（PLA2）、肌酐（Cr）、尿素氮（BUN）水平均明显低于缺血肾损伤组，肾小球滤过率（GFR）及肾血浆流量（RPF）则明显高于缺血肾损伤组；且PLA2与BUN、Cr呈正相关，而与GFR、RPF呈负相关。提示：粉防已碱可通过抑制PLA2活性的机制对急性缺血性肾损伤产生保护性作用。
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| 关 键 词： | 急性缺血性肾损伤 粉防己碱 磷脂酶A_2 大鼠 |
A Study on the Role of Tetrandrine for Acute Ischemic Renal Injury and the Relationship between Tetrandrine and Phospholipase A_2 |
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| Qian Lingmei, Wang Xiaoyun. A Study on the Role of Tetrandrine for Acute Ischemic Renal Injury and the Relationship between Tetrandrine and Phospholipase A_2[J]. Acta Universitatis Medicinalis Nanjing, 1998, 0(1) |
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| Authors: | Qian Lingmei Wang Xiaoyun |
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| Affiliation: | Qian Lingmei, Wang XiaoyunDepartment of Nephrology,The First Affiliated Hospital of Nanjing Medical Univercity,Nanjing 210029 |
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| Abstract: | Using a model for bilateral post-ischemic renal injury in rate developed by clamping renal pedicles for 45 minutes, the protective role of tetrandrine for acute ischemic renal injury and the relationship between tetrandrine and phospholipase A2 (PLA2) were observed. The results showed that serum levels of PLA2, creatinine (Cr) and blood urea nitrogen (BUN) in tetrandrine treated group (T group) were significantly lower than those in the control group (NT group). Meanwhile, the levels of glomerular filtration rate (GFR) and renal plasma flow (RPF) in T group were remarkably higher than those in NT group. PLA2 was in parallel with Cr and BUN, but not with GFR and RPF. It was suggested that tetrandrine can protect kidney against acute post-ischemic damage by inhibiting PLA2 activity. |
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| Keywords: | acute ischemic renal injury tetrandrine phospholipase A_2 rats |
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