| 44种生物碱类化合物对人胃癌细胞株BGC和人肝癌细胞株BEL-7402细胞增殖抑制活性的筛选 |
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| 引用本文： | 杨秀伟,冉福香,王瑞卿,吴军,彭俊,裴惠平,孙士勇.44种生物碱类化合物对人胃癌细胞株BGC和人肝癌细胞株BEL-7402细胞增殖抑制活性的筛选[J].中国现代中药,2007,9(2):6-9. |
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| 作者姓名： | 杨秀伟 冉福香 王瑞卿 吴军 彭俊 裴惠平 孙士勇 |
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| 作者单位： | 北京大学药学院天然药物及仿生药物国家重点实验室,北京,100083 |
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| 摘 要： | 目的：从中药中筛选有抗肿瘤活性的化合物。方法：应用人胃癌细胞株BGC和人肝癌细胞株BEL-7402筛选44种生物碱类化合物对其增殖的抑制作用。结果：伊波加因、哈尔明碱、黄连碱、小檗碱、延胡索碱、小檗胺、吐根碱、马兜铃酸Ⅰ、番茄碱苷、澳洲茄次碱、茄次碱、金鸡宁、罂粟碱和酒石酸麦角胺对人胃癌细胞株BGC细胞的增殖有一定程度的抑制作用。且呈浓度一效应关系；最强者为黄连碱、延胡索碱、小檗胺、吐根碱、番茄碱苷、澳洲茄次碱和金鸡宁，其次为伊波加因、哈尔明碱、小檗碱、马兜铃酸Ⅰ、茄次碱、罂粟碱和酒石酸麦角胺。蛇根精、γ-崖椒碱、黄连碱、小檗碱、延胡索碱、吐根碱、马兜铃酸Ⅰ、茄次碱和喜树碱对人肝癌细胞株BEL-7402细胞的增殖有一定程度的抑制作用，且呈浓度-效应关系；最强者为吐根碱、小檗碱、延胡索碱和喜树碱，其次为黄连碱、马兜铃酸Ⅰ和茄次碱。结论：上述生物碱类化合物可能是含有该生物碱、有抗肿瘤活性中药的有效成分，亦可能成为开发抗肿瘤新药的候选药物。
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| 关 键 词： | 中药 生物碱类 人胃癌细胞株BGC 人肝癌细胞株BEL-7402 |
| 收稿时间： | 2006-12-06 |
| 修稿时间： | 2006年12月6日 |
Inhibitory Effects of 44 Alkaloids Compounds Against Growth of Human Gastric Carcinoma Cell Line BGC and Human Hepatic Carcinoma Cell Line BEL-7402 in Vitro |
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| Yang Xiuwei,Ran Fuxiang,Wang Ruiqing,Wu Jun,Peng Jun,Pei Huiping and Sun Shiyong.Inhibitory Effects of 44 Alkaloids Compounds Against Growth of Human Gastric Carcinoma Cell Line BGC and Human Hepatic Carcinoma Cell Line BEL-7402 in Vitro[J].Modern Chinese Medicine,2007,9(2):6-9. |
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| Authors: | Yang Xiuwei Ran Fuxiang Wang Ruiqing Wu Jun Peng Jun Pei Huiping and Sun Shiyong |
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| Institution: | The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China;The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science, Peking University, Beijing 100083, China |
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| Abstract: | |
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| Keywords: | Traditional Chinese materials medica Alkaloids Human gastric carcinoma cell line BGC Human hepatic carcinoma cell line BEL- 7402 |
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