首发精神分裂症未治时间对神经认知功能P300和P50预后的影响研究

目的DUP（duration of unmedicated psychosis）指精神疾病患者首次正式开始抗精神病治疗以前其精神病状态持续存在的时间。本研究探讨首发精神分裂症DUP对其神经认知功能的影响。方法收集从未服药首次发作精神分裂症患者70例和正常对照者54例，并对50例患者完成为期2个月随访。应用诺丁汉发病量表评估患者的DUP，应用DUP中位值将患者分为长DUP组和短DUP组。应用事件相关电位P300和感觉门控P50抑制评估神经认知功能。结果与对照者相比，分裂症患者P300波幅降低（P〈0．01），P300潜伏期延迟（P〈0．01），感觉门控P50抑制值异常升高（P〈0．01）。治疗前，长DUP组的P300潜伏期较短DUP组有延迟（352．1ms±36．7ms，336．0ms±29．0ms；F=4．2，P〈0．05）。治疗2个月后，仅短DUP组患者的P300波幅有明显改善（5．41xV±3．01．LV，7．31．LV±2．6uV，F=8．1，P〈0．01）。同时，两组患者的感觉门控P50抑制改善均不显著。结论DUP对首发精神分裂症患者神经认知功能预后有显著影响。如何预防长DUP的发生，值得关注。

The influence of duration of unmedicated psychosis on the neurocognitive functions of drug-naive and first episode schizophrenia

Objective:Duration of unmedicated psychosis(DUP)is the period of one psychiatric illness from its occurrence to the initiation of antipsychotic medications.The present study was made to investigate the influence of DUP on the neurocognitive functions of schizophrenia.Methods:Seventy drug-naive and first episode schizophrenia patients and 54 normal controls were included.DUP was determined using Nottingham Onset Schedule(NOS)scale.The neurocognitive functions were evaluated using the P300 component of audito...