| Effect of Terazosin on Blood Pressure and Serum Lipids |
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| 作者姓名： | 龚培力 唐家荣 程龙献 陆再英 张金枝 曾繁典 |
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| 作者单位： | Department of Clinical Pharmacology，School of Basic Medical Sciences，Tongji Medical University，Wuhan 430030;Department of Cardiology，Tongji Hospital，Tongji Medical Univers |
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| 摘 要： | Ithasbeenreportedthatthemorbidityandmortalityofischemicheartdiseasescouldnotbereducedbytheantihyperten-sivemedicines.Forexample,g1ucoseto1er-anceandlipidmetabolismcouldbeaffectedbyusethiazinediuretics(>25mg/day)orcertain5b1ockersusedforcontrol1inghy-pertension'j.Thedisordersofmetabolismnotonlylimittheefficiencyoftheantihy-pertensivemedicinesbutalsoincreasethemorbidityofcomplicationsofcardiovasculardiseases.Terazosinisana,-blockerwithalong-termeffectthatdoesnotinducethedisordersofglucosetolera…
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| 收稿时间： | 23 February 1999 |
Effect of terazosin on blood pressure and serum lipids |
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| Gong Peili,Tang Jiarong,Cheng Longxian,Lu Zaiying,Zhang Jinzhi,Zeng Fandian.Effect of Terazosin on Blood Pressure and Serum Lipids[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1999,19(4):291-294. |
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| Authors: | Gong Peili Tang Jiarong Cheng Longxian Lu Zaiying Zhang Jinzhi Zeng Fandian |
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| Institution: | (1) Department of Clinical Pharmacology, School of Basic Medical Sciences, Tongji Medical University, 430030 Wuhan;(2) Department of Cardiology, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(3) Institute of Cardiovascular Diseases, Tongji Medical University, 430022 Wuhan |
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| Abstract: | Summary In an open multicenter prospective study, the effects of short-term (4 weeks. n=101) and long-term (6 months,n = 38) terazosin treatment on blood pressure, serum lipids and safety in the patients with mild to moderate essential hypertension
were observed. Mean systolic and diastolic blood pressure in sitting position were significantly reduced by 16. 4 % and 14.
0 % respectively (F<0. 01) after 4 weeks of terazosin therapy, with the total efficacy rate being 87. 1 %. During a 6 month
therapy, antihypertensive effect of terazosin could be maintained. Total cholesterol (TC) and low density lipoprotein (LDL)cholesterol
in serum were significantly decreasedP < 0. 05– 0. 01) in patients with hypercholesterolemia (TC≥6 mmol/ml)after 4 week terazosin treatment; the levels of TC, LDL
and triglyceride were significantly improved in hypertensive patients after 3–6 month terazosin treatment. The improvement
of lipid metabolism was related to the dosage of terazosin but not to antihypertensive effects of terazosin. The results suggested
that terazosin is effective in decreasing blood pressure and improving lipid metabolism. It may serve as a good antihypertensive
agent for hypertensive patients with hypercholesterolemia. |
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| Keywords: | terazosin essential hypertension lipid metabolism |
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