经胸腔留置管灌注化疗控制肺癌恶性胸腔积液疗效观察

目的观察经胸腔留置管行腔内灌注化疗控制肺癌恶性胸腔积液的疗效。方法72例肺癌并胸腔积液患者随机分为治疗组40例，采用胸腔留置管放液后灌注化疗：对照组32例，采用常规胸腔穿刺抽液后灌注化疗。化疗药物均选用顺铂60mg／kg，每周1次，2周为1周期，两周期后评定疗效。结果治疗组完全缓解20例，部分缓解17例，总有效率92．5％；对照组完全缓解12例，部分缓解14例，总有效率78．1％，两组比较有显著差异（P〈O．05）。结论经胸腔留置管行腔内灌注化疗，疗效好，创伤小，病人易接受，适合临床推广使用。

Treatment of malignant pleural effusion of lung cancer with thorax catheterization

Objective To observe the efficacy and safety of the chemotherapy by the thorax catheterization in treatment of malignant pleural effusion of lung cancer. Methods 72 cases of the patients with the malignant pleural effusion of lung cancer were randomly divided into groups, including treatment group （40 cases） with the thorax catheterization and control group（32 cases） with usual thoracentesis. The patients were treated with DDP, 60 mg/kg for weekly,1 cycle for 2 weeks. Results All effective rate of the treatment group was 92.5% with 20 cases of CR and 17 cases of PR, which was significantly higher than 78.1% of control group with 12 cases of CR and 14 cases of PR （P〈0.05 =. Conclusion The chemotherapy by thorax catheterization is safe and feasible in clinical.