| 紫杉烷类化合物的生物转化(英文) |
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| 引用本文： | 冯旭,邹忠梅,储智勇,孙迪安.紫杉烷类化合物的生物转化(英文)[J].中国天然药物,2011(6):466-472. |
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| 作者姓名： | 冯旭 邹忠梅 储智勇 孙迪安 |
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| 作者单位： | 北京协和医学院药用植研究所中草药物质基础与资源利用教育部重点实验室;中国人民解放军海军医学研究所; |
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| 基金项目： | supported by the National Natural Science Foundation of China (Nos.20772158,20972193); the Natural Science Foundation of Beijing (No.7092066); the New Drug Development Project of China (No.2009ZX09301-003)~~ |
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| 摘 要： | 微生物对紫杉烷类化合物进行转化可以获得一系列新的衍生物,其中一些衍生物具有潜在的药理活性,另外,生物转化还是制备药物代谢产物的一个非常有效的方法。本文综述了1996年至2010年紫杉烷类化合物生物转化研究的进展。
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| 关 键 词： | 生物转化 紫杉烷 |
Biotransformation of Taxanes |
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| FENG Xu ,ZOU Zhong-Mei ,CHU Zhi-Yong ,SUN Di-An Key Laboratory of Bioactive Substances , Resources Utilization of Chinese Herbal Medicine,Ministry of Education.Biotransformation of Taxanes[J].Chinese JOurnal of Natural Medicines,2011(6):466-472. |
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| Authors: | FENG Xu ZOU Zhong-Mei CHU Zhi-Yong SUN Di-An Key Laboratory of Bioactive Substances Resources Utilization of Chinese Herbal Medicine Ministry of Education |
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| Institution: | FENG Xu 1,2,ZOU Zhong-Mei 1,CHU Zhi-Yong 2,SUN Di-An 11 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Peking Union Medical College,Beijing 100193,China,2 Navy Medical Research Institute,Shanghai 200433 |
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| Abstract: | Microbial transformation of taxanes has provided new derivatives,some of which possess potential pharmacological activity.And microbial transformation can also be an efficient way to prepare drug metabolites.This article reviews the microbial transformation of taxanes from 1996 to 2010. |
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| Keywords: | Biotransformation Taxane |
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