| 液相色谱/质谱联用技术的新进展和中药研究的相关热点问题(英文) |
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| 引用本文： | 关天野,梁艳,李春竹,谢林,王广基,盛龙生. 液相色谱/质谱联用技术的新进展和中药研究的相关热点问题(英文)[J]. 中国天然药物, 2011, 0(5): 385-400 |
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| 作者姓名： | 关天野 梁艳 李春竹 谢林 王广基 盛龙生 |
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| 作者单位： | 中国药科大学药物代谢动力学重点实验室; |
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| 摘 要： | 中药的副作用较少,疗效确切且价格低廉。在中国,中药广泛应用于各种疾病的预防和治疗已经有上千年的历史。然而,中药成分的复杂性却成为其现代化和全球化进程中的瓶颈。本文综述了液相色谱/质谱联用(包括四级质谱、离子阱质谱、飞行时间质谱和杂交质谱)及数据处理技术应用于中药定性、定量研究的新进展。与此同时,本文还论述了与中药研究相关的一些热点问题,如质量控制,指纹图谱,多组分定性、定量,药物代谢动力学及代谢组学。此外,对于液相色谱/质谱联用技术应用于复杂组分研究的未来发展方向,如多重离子化质谱策略,多维液相色谱及纳升液相色谱也进行了简述。
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| 关 键 词： | 中药 液相色谱/质谱联用技术 |
Recent Development in Liquid Chromatography/Mass Spectrometry and Allied Topics for Traditional Chinese Medicine Research |
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| GUAN Tian-Ye,LIANG Yan,LI Chun-Zhu,XIE Lin,WANG Guang-Ji,SHENG Long-Sheng Key Lab of Drug Metabolism , Pharmacokinetics,China Pharmaceutical University,Nanjing ,China. Recent Development in Liquid Chromatography/Mass Spectrometry and Allied Topics for Traditional Chinese Medicine Research[J]. Chinese JOurnal of Natural Medicines, 2011, 0(5): 385-400 |
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| Authors: | GUAN Tian-Ye LIANG Yan LI Chun-Zhu XIE Lin WANG Guang-Ji SHENG Long-Sheng Key Lab of Drug Metabolism & Pharmacokinetics China Pharmaceutical University Nanjing China |
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| Affiliation: | GUAN Tian-Ye1,LIANG Yan1,LI Chun-Zhu,XIE Lin,WANG Guang-Ji,SHENG Long-Sheng Key Lab of Drug Metabolism & Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Traditional Chinese medicines(TCM) have been widely used for the prevention and treatment of various diseases for thousands of years in China,due to their less side-effect,proven efficacy and low cost.But the complexity of the components is still a bottleneck for its modernization and globalization.This paper reviews recent developments in liquid chromatography/mass spectrometry(including quadruple,ion traps,time-of-flight mass analyzers and hybrid instruments) and data processing techniques in the qualitat... |
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| Keywords: | Traditional Chinese medicine Liquid chromatography/mass spectrometry |
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