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Solid Tumor Inhibitory and other Constituents of Casimiroa tetrameria |
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| Authors: | XU Ya-Ming Maria del C.Ramirez-Ahumada Frederick A.Valeriote A.A.Leslie Gunatilaka Southwest Center for Natural Products Research Commercialization School of Natural Resources the Environment The University of Arizona E Valencia Road Tucson Arizona - USA Division of Hematology & Oncology Henry Ford Hospital Detroit Michigan |
| Affiliation: | XU Ya-Ming1,Maria del C.Ramirez-Ahumada1,Frederick A.Valeriote2,A.A.Leslie Gunatilaka1 Southwest Center for Natural Products Research and Commercialization,School of Natural Resources and the Environment,The University of Arizona,250 E Valencia Road,Tucson,Arizona 85706-6800,USA,2Division of Hematology & Oncology,Henry Ford Hospital,Detroit,Michigan 48202 |
| Abstract: | AIM:To isolate and characterize solid tumor inhibitory and other constituents from a bioactive extract of Casimiroa tetrameria((Rutaceae).METHODS:A crude extract of C.tetrameria obtained from the US National Cancer Institute Natural Product Repository and found to exhibit selective toxicity to solid tumor cells was subjected bioactivity-guided fractionation involving solvent-solvent partitioning,gel filtration,and chromatography.The structures of all isolated compounds were elucidated by spectroscopic analy... |
| Keywords: | Casimiroa tetrameria Rutaceae Solid tumor selectivity Flavonoids Zapotin Furanocoumarins N-benzoyltyramides |
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