| 趋化因子受体在嗜铬细胞瘤中的表达及意义 |
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| 引用本文： | 蔚青,肖家诚,吴华成,朱延波,崔斌,王卫庆,杨小妹,高亚博,金晓龙.趋化因子受体在嗜铬细胞瘤中的表达及意义[J].诊断学,2010,9(2):177-180. |
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| 作者姓名： | 蔚青 肖家诚 吴华成 朱延波 崔斌 王卫庆 杨小妹 高亚博 金晓龙 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院病理科;上海交通大学医学院附属瑞金医院内分泌代谢病科; |
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| 基金项目： | 上海市卫生局科研课题资助 |
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| 摘 要： | 目的:通过检测趋化因子受体(CXCR4)在肾上腺良性嗜铬细胞瘤(BPCC)和恶性嗜铬细胞瘤(MPCC)中的表达,探讨诊断MPCC的辅助指标,为鉴别嗜铬细胞瘤(PCC)的生物学行为提供依据。方法:选取1996至2009年期间我院临床资料和病理资料完整的PCC手术标本141例(其中BPCC113例为良性组,MPCC28例为恶性组),另取10例因良性肾疾患行肾切除时获取的同侧正常肾上腺髓质作为对照组。采用免疫组化技术检测BPCC、MPCC及对照组中CXCR4的表达;同时随机选取60例标本,其中BPCC40例,MPCC20例,对患者的临床资料进行统计分析。结果:CXCR4在MPCC组中的表达率为85.71%,明显高于其在BPCC组中的表达(38.05%),两组间差异有统计学意义(P<0.05)。临床资料示MPCC组发病年龄明显低于BPCC组,MPCC平均发病年龄为38岁,BPCC平均发病年龄为45岁(P<0.05)。结论:CXCR4可作为MPCC的预判指标。对年龄较轻的PCC患者,应警惕其为恶性的可能。
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| 关 键 词： | 肾上腺 嗜铬细胞瘤 趋化因子受体 |
Expression of CXCR4 in pheochromocytomas and its significance |
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| WEI Qinga,XIAO Jia-chenga,WU Hua-chenga,ZHU Yan-boa,CUI Binb,WANG Wei-qingb,YANG Xiao-meia,GAO Ya-boa,JIN Xiao-longa. a.Expression of CXCR4 in pheochromocytomas and its significance[J].Journal of Diagnostics Concepts & Practice,2010,9(2):177-180. |
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| Authors: | WEI Qinga XIAO Jia-chenga WU Hua-chenga ZHU Yan-boa CUI Binb WANG Wei-qingb YANG Xiao-meia GAO Ya-boa JIN Xiao-longa a |
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| Institution: | WEI Qinga,XIAO Jia-chenga,WU Hua-chenga,ZHU Yan-boa,CUI Binb,WANG Wei-qingb,YANG Xiao-meia,GAO Ya-boa,JIN Xiao-longa. a. Department of Pathology,b. Department of Endocrine , Metabolic Diseases,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China |
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| Abstract: | Objective To investigate the expression of chemokine receptor (CXCR4) in benign pheochromocytoma (BPCC) and malignant pheochromocytoma (MPCC)for seeking an useful auxiliary marker for the diagnosis of MPCC. Methods One hundred and forty-one surgical specimens of pheochromocytoma (PCC),including 113 BPCC and 28 MPCC,were collected from the pathological file in the department of pathology,Ruijin Hospital during the period 1996-2009. Normal adrenal glands taken from 10 patients undergoing nephrectomy for benig... |
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| Keywords: | Adrenal gland Pheochromocytoma Chemokine receptor |
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