| 雷贝拉唑联合马来酸曲美布汀治疗反流性食管炎 |
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| 引用本文： | 邢开慧,马方兰.雷贝拉唑联合马来酸曲美布汀治疗反流性食管炎[J].西部医学,2008,20(2):315-316. |
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| 作者姓名： | 邢开慧 马方兰 |
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| 作者单位： | 西昌市人民医院消化内科,四川,西昌,615000 |
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| 摘 要： | 目的观察雷贝拉唑联合马来酸曲美布汀治疗反流性食管炎（RE）的临床疗效和安全性。方法将112例RE患者随机分为A、B两组，每组各56例，两组均予马来酸曲美布汀100mg，3次／d，A组加服雷贝拉唑20mg，1次／d，B组加服雷尼替丁150mg，2次／d，分别于治疗前、治疗后4、8周观察临床症状及胃镜变化。结果治疗后4、8周A组的临床症状改善、胃镜检查食管粘膜病损愈合率均优于B组（P〈0．01）。结论雷贝拉唑联合马来酸曲美布汀治疗RE疗效明显优于雷尼替丁联合马来酸曲美布汀。
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| 关 键 词： | 反流性食管炎 雷贝拉唑 马来酸曲美布汀 |
| 文章编号： | 1672-3511(2008)02-0315-02 |
| 修稿时间： | 2007年11月20 |
Rabeprazole and Trimebutine for treatment of reflux esophagitis |
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| XING Kai-hui,MA Fang-lan.Rabeprazole and Trimebutine for treatment of reflux esophagitis[J].Medical Journal of West China,2008,20(2):315-316. |
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| Authors: | XING Kai-hui MA Fang-lan |
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| Institution: | (Department of Gastroenterology, People＇s Hospital of Xichang, Xichang 615000, Sichuan, China) |
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| Abstract: | Objective To investigate the efficacy and safety of Rabeprazole and Trimebutine in the treatment of reflux esophagitis（RE）. Methods 112 cases of RE were randomized to 2 groups： group A group B with 56 cases in each group. Both groups were treated with Trimebutine, 100 mg three times daily. Group A were added with Rabeprazole 20mg once daily. Group B were added with Ranitidine 150mg twice daily. Clinical manifestations and gastroscopy results were observed before and 4 weeks, 8 weeks after treatment. Results The total effective rate and the healing rate of esophageal mucosal lesion in group A was higher than that of group B at 4 and 8 weeks after treatment （P〈0. 01）. Conclusion The efficacy of Rabeprazole and Trimebutine in the treatment of RE is better than that of Ranitidine and Trimebutine. |
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| Keywords: | Reflux esophagitis Rabeprazole Trimebutine |
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