Association between coronary artery calcium and thoracic spine bone mineral density: Multiethnic Study of Atherosclerosis (MESA) |
| |
| Institution: | 1. Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, USA;2. Vanderbilt University Medical Center, Nashville, TN, USA;1. High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia;2. Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia;3. Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Tunisia;4. Montreal Clinical Research Institute, Montreal, Canada;5. Université de Lille, Université d''Artois, Université du Littoral Côte d''Opale, ULR 7369-URePSSS-Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, France;6. Hematology laboratory, CHU Habib Bourguiba, Sfax, Tunisia;7. Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2), UFR STAPS, UPL, Paris Nanterre, Nanterre, France;1. School of Nutrition Science, University of Milan, Milan, Italy;2. Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK;3. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;1. Department of Medicine – DIMED, University of Padua, Italy;2. Department of Pharmaceutical and Pharmacological Sciences (DSF), University of Padua, Italy;1. Department of Food and Drug, University of Parma, Parma, Italy;2. Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, Italy;3. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy;4. Department of Chemistry, Life Science, And Environmental Sustainability, University of Parma, Parma, Italy;1. CNR-IFC, Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy;2. Division of Vascular Surgery, Department of Clinical and Experimental Sciences, University of Brescia and Spedali Civili Hospital, Brescia, Italy;3. Section of Pathology, University of Brescia, Italy;4. Unità Operativa di Nefrologia e Trapianto renale, Grande Ospedale Metropolitano, Reggio Calabria, Italy;5. Division of Nephrology, Department of Internal Medicine, Koc University School of Medicine, Istanbul 34010, Turkey;6. Ethics Committee, University of Brescia and Spedali Civili Hospital, Brescia, Italy;7. Renal Research Institute, New York, USA and Institute of Molecular Biology and Genetics (BIOGEM), Ariano Iripino, Italy and Associazione Ipertensione Nefrologia e Trapianto Renale (IPNET), Reggio Calabria, Italy |
| |
| Abstract: | Background and aimsPreviously, osteoporosis and coronary artery disease were considered unrelated. However, beyond age, these two conditions appear to share common etiologies that are not yet fully understood. We examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score.Methods and resultsMESA is a prospective cohort study of 6814 men and women between the ages of 45 and 84 years, without clinical cardiovascular disease. This study included participants who underwent non-contrast chest CT scans to determine CAC score and thoracic spine BMD. The thoracic spine BMD was categorized into osteoporosis (defined as T score: ≤ ?2.5), osteopenia (T-score between: ?2.5 and ?1) and normal BMD (T-score ≥ ?1). There were 3392 subjects who had CAC >0 at baseline. The prevalence of CAC >0 was 36% in normal BMD group, 49% in the osteopenia and 68% in osteoporosis group. After adjusting for risk factors of atherosclerosis, in multivariate regression models we found a significant association between CAC and osteoporosis (OR: 1.40, 95% CI 1.16–1.69, p value < 0.0004). Furthermore, we stratified our results by gender and found a statistically significant association in both men and women.ConclusionResults from this cross-sectional analysis of a large population based ethnically diverse cohort indicate a significant inverse relationship between thoracic BMD and CAC in both genders independent of other cardiovascular risk factors. Future studies need to explore the underlying pathophysiological mechanisms relating BMD and coronary artery calcification. |
| |
| Keywords: | Osteoporosis CVD Coronary calcium BMD Atherosclerosis CT |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
