Tenofovir induced Fanconi syndrome: A possible pharmacokinetic interaction |
| |
| Authors: | Jigar Kapadia Samidh Shah Chetna Desai Mira Desai Shivani Patel Asha N Shah R K Dikshit |
| |
| Institution: | Department of Pharmacology, B. J. Medical College, Ahmedabad, India;1.Department of Medicine, B. J. Medical College, Ahmedabad, India;2.Department of Medicine and Nodal Officer, ART Center, Civil Hospital, Ahmedabad, India |
| |
| Abstract: | Tenofovir was introduced as a second line drug for the treatment of human immunodeficiency virus (HIV) infection in India in December 2009. Although rare, renal toxicity is a recognized adverse drug reaction (ADR) of this drug, especially when administered with boosted lopinavir-ritonavir. In this case, an HIV positive patient receiving tenofovir based antiretroviral therapy (ART) for last 1 year developed albuminuria, glycosuria and hypophosphatemia. Renal function tests and random blood sugar were within normal limits. He was diagnosed as a case of tenofovir induced Fanconi syndrome. Tenofovir was discontinued and patient was prescribed an alternate regimen. Five months later clinical symptoms and renal functions returned to normal. A pharmacokinetic interaction between tenofovir and ritonavir may have resulted in the toxicity. A periodic monitoring of renal functions is desirable in patients on tenofovir based ART.KEY WORDS: Adverse drug reaction, Fanconi syndrome, protease inhibitor, tenofovir |
| |
| Keywords: | |
|
|
