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Identification,validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy
Affiliation:1. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland;2. Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université de Paris, Paris, France;3. Paris Brain Institute (ICM), CNRS UMR 7225, Inserm U 1127, UPMC-P6 UMR S 1127, Hôpital de la Pitié—Salpêtrière, Paris, France;4. National Centre of Neurosurgery, Beaumont Hospital, Dublin, Ireland;5. VIB-KU Leuven Center for Cancer Biology, Department of Oncology, Leuven, Belgium;6. Epidemiology & Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland;7. Duke Cancer Institute, Duke University, Durham, USA;8. Department of Systems Biology at Columbia University, New York, USA;9. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, USA;10. Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, USA;11. Sorbonne Université, Inserm, CNRS, UMR S 1127, Paris Brain Institute (ICM), AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière—Charles Foix, Paris, France;12. Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium;13. VIB Center for Cancer Biology, Leuven, Belgium;14. Department of Neurosurgery, Brain Tumor Center, Erasmus University Medical Center, Rotterdam, the Netherlands;15. Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands;16. Department of Neuropathology, Beaumont Hospital, Dublin, Ireland;17. Information Technology for Translational Medicine (ITTM), Luxembourg, Luxembourg;18. The Jackson Laboratory for Genomic Medicine, Farmington, USA;19. Department of Neurosurgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, the Netherlands
Abstract:
Keywords:tumour microenvironment  subtypes  immunotherapy  precision therapy
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