Therapeutic induction of autophagy to modulate neurodegenerative disease progression |
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| Authors: | Warren E Hochfeld Shirley Lee David C Rubinsztein |
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| Affiliation: | 1.Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, United Kingdom |
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| Abstract: | There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington''s disease (HD), Parkinson''s disease (PD) and amyotropic lateral sclerosis. |
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| Keywords: | autophagy neurodegenerative disease Alzheimer disease Huntington''s disease Parkinson''s disease amyotropic lateral sclerosis mTOR rapamycin IP3 lithium |
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