c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer |
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| Authors: | Ercan Yilmaz Onder Celik Yavuz Simsek Ilgin Turkcuoglu Ebru Celik Mehmet Gül Seyma Hascalik Engin Aydin |
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| Institution: | Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ercanyilmazgyn@yahoo.com |
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| Abstract: | Purpose To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer. Methods Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry. Results c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia. Conclusions Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion. |
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