Paraventricular nucleus anandamide signaling alters eating and substrate oxidation |
| |
Authors: | Chapman Colin D Dono Lindsey M French Matthew C Weinberg Zachary Y Schuette Lindsey M Currie Paul J |
| |
Affiliation: | Department of Psychology, Reed College, 3203 SE Woodstock Blvd, Portland, Oregon 97202, USA. |
| |
Abstract: | In the central nervous system, the endocannabinoid anandamide [N-arachidonoylethanolamine (AEA)] is believed to increase food intake through on-demand activation of hypothalamic circuits. The present study examined the effects of hypothalamic paraventricular nucleus (PVN) injections of AEA (25-400 pmol) on food intake and energy substrate oxidation [respiratory quotient (RQ)]. PVN administration of AEA increased eating behavior and RQ, indicating enhanced carbohydrate oxidation. Further, PVN administration of the cannabinoid type 1 receptor inverse agonist AM251 (5-10 μg) attenuated both the eating and the RQ responses elicited by AEA (100 pmol). AM251 administered alone did not alter food intake or RQ. Overall, these findings are consistent with a role for PVN cannabinoid type 1 receptors in the regulation of eating and energy homeostasis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|