| 鼠半胱氨酸蛋白酶抑制物cystatin S 对人口腔牙龈卟啉菌生长的抑制 |
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| 引用本文： | 李鸣宇,刘正,梅本利彦. 鼠半胱氨酸蛋白酶抑制物cystatin S 对人口腔牙龈卟啉菌生长的抑制[J]. 牙体牙髓牙周病学杂志, 1998, 0(4) |
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| 作者姓名： | 李鸣宇 刘正 梅本利彦 |
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| 作者单位： | 上海第二医科大学附属第九人民医院口腔医学研究所，日本朝日大学口腔细菌学教室 |
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| 摘 要： | 目的：观察鼠半胱氨酸蛋白酶抑制物ｃｙｓｔａｔｉｎＳ对人口腔牙龈卟啉菌（Ｐｏｒｐｈｙｒｏｍｏｎａｓｇｉｎｇｉｖａｌｉｓ）生长的影响。方法：用琼脂扩散法检查了ｃｙｓｔａｔｉｎＳ对人口腔数种牙龈卟啉菌生长的抑制情况。结果：虽然对不同菌株其影响程度略有差异，对实验用牙龈卟啉菌３８１，３８１Ｐ，ＡＴＣＣＷ５０，Ｗ８３，３３２７７，ＮＣＴＣ１１８３４，ＶＰＩ１４０１８生长均有抑制作用，并且具有药物浓度依赖性。结论：鼠半胱氨酸蛋白酶抑制物ｃｙｓｔａｔｉｎＳ对人口腔牙龈卟啉菌生长有抑制作用。
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| 关 键 词： | 半胱氨酸蛋白酶 cystatin S 牙龈卟啉菌 |
The inhibition of porphyromonas gingivalis by rat cystatin S |
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| Li Mingyu,Liu Zheng,Umemoto Toshihiro Institute of Stomatology,Shanghai Second Medical University,Shanghai. The inhibition of porphyromonas gingivalis by rat cystatin S[J]. Chinese Journal of Conservative Dentistry, 1998, 0(4) |
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| Authors: | Li Mingyu Liu Zheng Umemoto Toshihiro Institute of Stomatology Shanghai Second Medical University Shanghai |
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| Affiliation: | Li Mingyu,Liu Zheng,Umemoto Toshihiro Institute of Stomatology,Shanghai Second Medical University,Shanghai 200011 |
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| Abstract: | Aim: To study the effect of rat cystatin S on porphyromonas gingivalis. Methods: Agar diffusion was used to analyse the effect of rat cystatin S on P.gingivalis. Results: Rat cystatin S, a cysteine proteinase inhibitor, inhibited the growth of all tested strains of a human oral, Gram-negative anaerobic periodontopathogen P.gingivalis by dose dependent manner. Conclusions: The specific inhibitory activity of cystatin S against this tissue-invasive bacterium but not against other oral bacterial species emphasized the importance of specific cysteine proteinases for growth of P.gingivalis |
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| Keywords: | cysteine proteinase cystatin S porphyromonas gingivalis |
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