微量元素锌、铜、硒对胎盘镉转运的影响

目的:评价微量元素锌、铜、硒对胎盘镉转运的影响。方法:于2002年11月至2003年1月选择湖北省大冶市的待产孕妇,进行问卷调查和体格检查,同时检测全血锌、铜、硒和镉水平。采集新生儿脐血和胎盘标本用于测定镉含量。分析孕妇锌、铜、硒的营养状况是否与胎盘镉转运存在显著关联。结果:47例20～34岁孕妇全血镉(μg/L)为0.8～25.2,新生儿脐血镉(μg/L)为0.020～1.48,孕妇血镉显著高于脐血镉(T=564P<0.01)。孕妇胎盘组织镉含量(μg/g干重)为0.082～3.97。多因素线性回归分析显示,低血铜孕妇与血铜水平正常者相比新生儿脐血镉显著增加,低血锌孕妇的胎盘镉显著高于血锌正常者,低血硒孕妇的胎盘镉显著低于血硒正常者。结论:微量元素铜、锌、硒可能影响胎盘镉转运。

EFFECT OF ESSENTIAL ELEMENTS ZINC, COPPER, AND SELENIUM ON PLACENTAL CADMIUM TRANSPORT

Objective: To evaluate the potential effect of zinc, copper, and selenium on placental cadmium transport. Methods: Pregnant women were selected from Daye,Hubei Province. Whole blood, cord blood and placenta were collected, and Cd levels were determined by inductively coupled plasma emission mass spectroscopy. Zn, Cu, and Se levels in whole blood were also determined. The potential association between essential elements and placental Cd transport was evaluated. Results: Whole blood Cd (0.8–25.2ìg/L) in 47 pregnant women aged 20 to 34 years was significantly higher than that in cord blood(0.020–1.48ìg/L). Placental Cd ranged from 0.082 to 3.97 ìg/g dry weight. Multiple linear regression indicated that lower maternal blood Cu was significantly associated with higher cord blood Cd. Placental Cd in pregnant women with lower maternal Zn was significantly higher than that in those with normal Zn level. Placental Cd in pregnant women with lower maternal Se was significantly lower than that in those with normal Se level. Conclusion: Essential elements, such as Cu, Se, and Zn might affect placental Cd transport.