PTEN蛋白在垂体瘤中的表达及其意义

目的:探讨垂体瘤中抑癌基因pten编码产物的表达情况及临床病理意义.方法:应用免疫组织化学技术检测36例垂体肿瘤及6例正常脑组织中PTEN蛋白的表达情况.结果:对照组6例正常脑组织PTEN表达全部阳性,强阳性率为83.3％(5/6);28例非侵袭垂体瘤中PTEN的阳性表达率为78.5％(22/28),强阳性率为35.7％(10/28),阳性信号存在于胞质中,与正常对照组比较强阳性率差异有统计学意义(P<0.05);而8例侵袭性垂体瘤(包括1例垂体癌)中PTEN无强阳性表达,阳性率为25.0％(2/8),与正常对照组及非侵袭性垂体瘤比较皆有显著性差异(P<0.01).结论:垂体瘤的发生发展中存在pten基因的失活现象,它的阳性表达与垂体瘤的侵袭性和预后相关.

Expression of PTEN protein in pituitary tumor

Objective:To investigate the protein expression of tumor suppressor gene pten in pituitary tumor.Methods:A total of 36 cases of pituitary tumor tissues and 6 cases of normal brain after brain trauma surgery were analyzed for PTEN protein expression by immunohistochemical method.Results:The strong positive rate was 83.3%(5/6) in normal brain and 35.7%(10/28) in 28 cases of non invasive pituitary tumor.There was significant difference between them in the pattern of PTEN protein expression( P <0.05).The positive rate was 100.0% in normal brain and 25.0%(2/8) in 8 cases of invasive pituitary tumor and pituitary carcinoma.There was significant difference between them in the pattern of PTEN protein expression( P <0.01).Conclusion:It is indicated that pten gene inactivation may play a role in the genesis and development of pituitary tumor.