| 染色体17p13.3肿瘤杂合性缺失区域内外显子的分离 |
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| 引用本文： | 郭鸣雷,赵新泰,万大方.染色体17p13.3肿瘤杂合性缺失区域内外显子的分离[J].肿瘤,2000,20(4):290-292. |
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| 作者姓名： | 郭鸣雷 赵新泰 万大方 |
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| 作者单位： | 上海市肿瘤研究所癌基因与相关基因国家重点实验室!上海200032 |
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| 摘 要： | 目的 在染色体１７ｐ１３．３杂合性缺失区域内进行表达的分离。方法 采用外显子搏获法对位于１７ｐ１３．３杂合性缺失区域内的ＢＡＣ基因组克隆进行外显子的分离。结果 在获得的克隆中，４个克隆为已知基因的外显子，另４个史隆属于３个上显子（２个克隆中的外显子片段序列一致）。结论 在染色体１７ｐ１３．３杂合性缺失区域内获得了一些表达序列。
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| 关 键 词： | 杂合性缺失 外显子捕获 染色体17 肿瘤 |
ISOLATION OF EXONS ON THE LOSS OF HETEROZYGOSITY REGION OF CHROMOSOME 17p13.3 IN TUMORS BY EXON TRAPPING |
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| GUO Ming lei,ZHAO Xin tai,WAN Da fang,et al..ISOLATION OF EXONS ON THE LOSS OF HETEROZYGOSITY REGION OF CHROMOSOME 17p13.3 IN TUMORS BY EXON TRAPPING[J].Tumor,2000,20(4):290-292. |
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| Authors: | GUO Ming lei ZHAO Xin tai WAN Da fang |
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| Institution: | Shanghai 200032.P.R.China |
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| Abstract: | Objective Isolation of expression sequence on the Loss of Heterozygosity (LOH) region on chromosome 17p13 3 was caried out.Methods Exon trapping.Results Eight exons were isolated ,4 of them are exons of known genes and the others are novel.Conclusion Some exons on the LOH region of chromosome 17p13 3 were obtained.$$$$ |
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| Keywords: | Loss of heterozygosity (LOH) Exon Trapping |
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