| 肉桂酸对人肺腺癌A549细胞相关基因表达的影响 |
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| 引用本文： | 范天黎,许培荣,杨静,王霞,杨观瑞. 肉桂酸对人肺腺癌A549细胞相关基因表达的影响[J]. 山东医药, 2006, 46(34): 8-9 |
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| 作者姓名： | 范天黎 许培荣 杨静 王霞 杨观瑞 |
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| 作者单位： | 郑州大学医学科学研究所,河南,郑州,450052;郑州大学细胞生物学研究室,河南,郑州,450052;Marion Bessin Liver Research Center Albert Einstein College of Medicine |
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| 摘 要： | 目的探讨肉桂酸（CINN）诱导肺癌A549细胞分化的能力及其分子机制。方法采用原位杂交和完整细胞原位斑点印迹等技术，研究CINN对人肺腺癌A549细胞分化相关蛋白质分子CD15，相关基因c-myc、EGFR、wtp53、wtp16等表达的影响。结果CINN可上调wtp53、wtp16基因，抑制CD15、c-myc、EGFR基因表达。结论CINN的上述作用可能是其诱导肺癌A549细胞分化的机制之一。
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| 关 键 词： | 肉桂酸 A549细胞 分化诱导 原位杂交 免疫组织化学 |
| 文章编号： | 1002-266X（2006）34-0008-02 |
| 收稿时间： | 2006-06-24 |
| 修稿时间： | 2006-06-24 |
Effects of cinnamic acid on correlative gene expression of A549 cells in human lung cancer |
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| FAN Tian-li,XU Pei-rong,YANG Jing,WANG Xia,YANG Guan-rui. Effects of cinnamic acid on correlative gene expression of A549 cells in human lung cancer[J]. Shandong Medical Journal, 2006, 46(34): 8-9 |
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| Authors: | FAN Tian-li XU Pei-rong YANG Jing WANG Xia YANG Guan-rui |
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| Affiliation: | 1 Medical Science Research Center, Zhengzhou University, Zhouzhou 450052, P. R. China |
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| Abstract: | [Objective] To investigate the differentiation ability and the molecule mechanism of pulmonary A549 cells induced by cinnamic acid(CINN).[Methods] The hybridization in siu and whole cells immunoblotting in situ were used to study the effect of CINN on expression of A549 cells differentiating correlative protein CD15,correlative gene c-myc?EGFR?wtp53?wtp16,etc in human lung cancer. [Results] CINN could up-regulate the expression of wtp53?wtp16 gene and restrain the expression of CD15?c-myc?EGFR gene.[Conclusion] The action of CINN mentioned above is perhaps one of the mechanisms of inducing lung cancer A549 cells to differentiate. |
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| Keywords: | cinnamic acid A549 cells differentiation inducer in situ hybridization nohistochemistry |
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