| 原发性胃弥漫大B细胞淋巴瘤69例临床分析 |
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| 引用本文： | 王小沛,郑文,刘卫平,谢彦,涂梅峰,林宁晶,宋玉琴,平凌燕,应志涛,邓丽娟,张晨,朱军.原发性胃弥漫大B细胞淋巴瘤69例临床分析[J].肿瘤,2011,31(11):1036-1041. |
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| 作者姓名： | 王小沛 郑文 刘卫平 谢彦 涂梅峰 林宁晶 宋玉琴 平凌燕 应志涛 邓丽娟 张晨 朱军 |
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| 作者单位： | 北京大学肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142 |
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| 摘 要： | 目的:探讨原发性胃弥漫大B细胞淋巴瘤(primary gastric diffuse large B-cell lymphoma,PGDLBCL)的诊断、治疗和预后。方法:回顾性分析2007年1月—2009年12月收治的69例PGDLBCL患者的临床表现、诊断、治疗和预后以及临床病理因素与疗效和预后的关系。结果:PGDLBCL患者占本院同期收治淋巴瘤患者的10.44%(69/661),其中男性29例,女性40例,中位年龄为54岁(21～78岁)。主要临床表现为腹痛、腹胀和黑粪。本组患者接受以化疗为主的综合治疗,完全缓解率为37.7%(26/69),部分缓解率为46.4%(32/69),总有效率为81.4%(58/69)。单因素分析结果显示,血清乳酸脱氢酶水平升高患者的疗效较差(P<0.05)。全组患者的1、2和3年总生存率分别为89.2%、84.2%和81.3%。单因素分析显示,年龄、国际预后指数(international prognostic index,IPI)和血清乳酸脱氢酶水平是影响预后的因素;多因素分析结果显示,仅血清乳酸脱氢酶水平是影响预后的因素。结论:PGDLBCL以女性居多,多采用以化疗为主的综合治疗,治疗中应注意消化管出血和穿孔的预防与处理。乳酸脱氢酶是重要的预后因素。
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| 关 键 词： | 淋巴瘤 大B-细胞 扩散 胃 诊断 治疗 预后 |
Clinical analysis of 69 patients with primary gastric diffuse large B-cell lymphoma |
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| WANG Xiao-pei,ZHENG Wen,LIU Wei-ping,XIE Yan,TU Mei-feng,LIN Ning-jing,SONG Yu-qin,PING Ling-yan,YING Zhi-tao,DENG Li-juan,ZHANG Chen,ZHU Jun.Clinical analysis of 69 patients with primary gastric diffuse large B-cell lymphoma[J].Tumor,2011,31(11):1036-1041. |
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| Authors: | WANG Xiao-pei ZHENG Wen LIU Wei-ping XIE Yan TU Mei-feng LIN Ning-jing SONG Yu-qin PING Ling-yan YING Zhi-tao DENG Li-juan ZHANG Chen ZHU Jun |
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| Institution: | WANG Xiao-pei,ZHENG Wen,LIU Wei-ping,XIE Yan,TU Mei-feng,LIN Ning-jing,SONG Yu-qin,PING Ling-yan,YING Zhi-tao,DENG Li-juan,ZHANG Chen,ZHU Jun Key Laboratory of Carcinogenesis and Translational Research of Ministry of Education,Peking University Cancer Hospital & Institute,Beijing 100142,China |
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| Abstract: | Objective:To analyze the diagnosis,treatment and prognosis of primary gastric diffuse large B-cell lymphoma(PGDLBCL).Methods:Retrospective analysis was conducted in 69 cases of PGDLBCL between January 2007 and December 2009.The data of clinical presentations,diagnosis,treatment and prognosis were collected,and the association of clinicopathological features with treatment outcomes and prognosis was analyzed.Results:PGDLBCL comprised about 10.44%(69/661) of all lymphomas,including 29 males and 40 females;the... |
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| Keywords: | Lymphoma large B-Cell diffuse Stomach Diagnosis Therapy Prognosis |
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