| 局部晚期乳腺癌1081例临床病理特征及预后分析 |
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| 引用本文： | 刘晓东,佟仲生,李淑芬,史业辉,汪旭,郝春芳.局部晚期乳腺癌1081例临床病理特征及预后分析[J].肿瘤,2011,31(10):918-923. |
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| 作者姓名： | 刘晓东 佟仲生 李淑芬 史业辉 汪旭 郝春芳 |
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| 作者单位： | 天津医科大学附属肿瘤医院乳腺内科,乳腺癌防治教育部重点实验室,天津市肿瘤防治重点实验室,天津300060 |
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| 基金项目： | 天津市应用基础及前沿技术研究计划(编号:10JCYBJC11500) |
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| 摘 要： | 目的:分析局部晚期乳腺癌患者的临床病理学特征及生存状态,探讨其预后的独立影响因素。方法:回顾性分析2001年7月—2004年12月本院收治的1081例局部晚期乳腺癌患者的临床病理特征、复发和转移以及生存情况。采用Kaplan-Meier法进行预后的单因素分析,COX回归模型进行多因素分析。结果:局部晚期乳腺癌患者3年和5年无病生存率分别为69.6%和56.9%,3年和5年总生存率分别为81.5%和65.9%。单因素分析结果显示,影响局部晚期乳腺癌患者预后的因素包括肿瘤家族史、肿瘤大小、淋巴结状态、组织学分级、辅助化疗、放疗和内分泌治疗。多因素分析结果显示,肿瘤大小、淋巴结状态、辅助化疗、放疗和内分泌治疗是影响局部晚期乳腺癌患者预后的独立因素。结论:术后辅助化疗、放疗和内分泌治疗可明显改善患者的预后。对局部晚期乳腺癌应根据临床病理特征,综合应用上述治疗方法实现个体化治疗。
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| 关 键 词： | 乳腺肿瘤 治疗结果 预后 |
Analysis of clinicopathological features and prognostic factors of 1 081 patients with locally advanced breast cancer |
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| LIU Xiao-dong,TONG Zhong-sheng,LI Shu-fen,SHI Ye-hui,WANG Xu,HAO Chun-fang.Analysis of clinicopathological features and prognostic factors of 1 081 patients with locally advanced breast cancer[J].Tumor,2011,31(10):918-923. |
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| Authors: | LIU Xiao-dong TONG Zhong-sheng LI Shu-fen SHI Ye-hui WANG Xu HAO Chun-fang |
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| Institution: | LIU Xiao-dong,TONG Zhong-sheng,LI Shu-fen,SHI Ye-hui,WANG Xu,HAO Chun-fang Department of Breast Cancer Medical Oncology,Cancer Hospital of Tianjin Medical University,Key Laboratory of Breast Cancer Prevention and Therapy(Ministry of Education),Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China |
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| Abstract: | Objective:To analyze the clinicopathological features and survival in patients with locally advanced breast cancer(LABC),and to explore the prognostic factors of LABC.Methods:The clinicopathological features,recurrence,metastasis and survival of 1 081 patients with LABC between July 2001 and December 2004 were retrospectively analyzed.Univariate analysis for prognosis was performed by Kaplan-Meier method.COX regression model was applied for multivariate prognostic analysis.Results:The 3-and 5-year disease-f... |
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| Keywords: | Breast neoplasms Treatment outcomes Prognosis |
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